Toward better control of classical swine fever in wild boars: susceptibility of boar-pig hybrids to a recent Japanese isolate and effectiveness of a bait vaccine

• Main Authors: Katsuhiko Fukai, Tatsuya Nishi, Manabu Yamada, Mitsutaka Ikezawa
• Format: Article
• Language: English
• Published: BMC 2020-07-01
• Series: Veterinary Research
• Subjects: bait vaccine; classical swine fever virus; experimental infection; pathogenicity; wild boars
• Online Access: http://link.springer.com/article/10.1186/s13567-020-00821-w
• ISSN: 1297-9716

Abstract We analyzed the pathogenicity of a recent Japanese classical swine fever virus (CSFV) to wild boars via an experimental infection using boar-pig hybrids as an alternative to wild boars. We also investigated the effectiveness of a bait vaccine against the CSFV. Naïve boar-pig hybrids and pigs showed clinical signs such as fever, leucopenia, anorexia and conjunctivitis following the experimental infection. In contrast, the boar-pig hybrids administered the bait vaccine did not show any clinical signs. Our data indicated that boar-pig hybrids and domestic pigs have similar susceptibility to the recent Japanese CSFV. Additionally, the bait vaccine is effective against the CSFV.