Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) study
Background: Exposure to household air pollution from solid fuel combustion for cooking and heating is an important risk factor for premature death and disability worldwide. Current evidence supports an association of ambient air pollution with cardiovascular disease but is limited for household air...
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Format: | Article |
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Elsevier
2021-01-01
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Series: | Environment International |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020322091 |
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doaj-8ebf2992053c47d2b8ef3756c17e654d |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tom Cole-Hunter Radhika Dhingra Kristen M. Fedak Nicholas Good Christian L'Orange Gary Luckasen John Mehaffy Ethan Walker Ander Wilson John Balmes Robert D. Brook Maggie L. Clark Robert B. Devlin John Volckens Jennifer L. Peel |
spellingShingle |
Tom Cole-Hunter Radhika Dhingra Kristen M. Fedak Nicholas Good Christian L'Orange Gary Luckasen John Mehaffy Ethan Walker Ander Wilson John Balmes Robert D. Brook Maggie L. Clark Robert B. Devlin John Volckens Jennifer L. Peel Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) study Environment International Cookstove Fine particulate matter Household air pollution Healthy adult Heart rate variability Cardiac repolarization |
author_facet |
Tom Cole-Hunter Radhika Dhingra Kristen M. Fedak Nicholas Good Christian L'Orange Gary Luckasen John Mehaffy Ethan Walker Ander Wilson John Balmes Robert D. Brook Maggie L. Clark Robert B. Devlin John Volckens Jennifer L. Peel |
author_sort |
Tom Cole-Hunter |
title |
Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) study |
title_short |
Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) study |
title_full |
Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) study |
title_fullStr |
Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) study |
title_full_unstemmed |
Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) study |
title_sort |
short-term differences in cardiac function following controlled exposure to cookstove air pollution: the subclinical tests on volunteers exposed to smoke (stoves) study |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-01-01 |
description |
Background: Exposure to household air pollution from solid fuel combustion for cooking and heating is an important risk factor for premature death and disability worldwide. Current evidence supports an association of ambient air pollution with cardiovascular disease but is limited for household air pollution and for cardiac function. Controlled exposure studies can complement evidence provided by field studies. Objectives: To investigate effects of short-term, controlled exposures to emissions from five cookstoves on measures of cardiac function. Methods: Forty-eight healthy adults (46% female; 20–36 years) participated in six, 2-h exposures (‘treatments’), including emissions from five cookstoves and a filtered-air control. Target fine particulate matter (PM2.5) exposure-concentrations per treatment were: control, 0 µg/m3; liquefied petroleum gas, 10 µg/m3; gasifier, 35 µg/m3; fan rocket, 100 µg/m3; rocket elbow, 250 µg/m3; and three stone fire, 500 µg/m3. Participants were treated in a set (pre-randomized) sequence as groups of 4 to minimize order bias and time-varying confounders. Heart rate variability (HRV) and cardiac repolarization metrics were calculated as 5-min means immediately and at 3 h following treatment, for analysis in linear mixed-effects models comparing cookstove to control. Results: Short-term differences in SDNN (standard deviation of duration of all NN intervals) and VLF (very-low frequency power) existed for several cookstoves compared to control. While all cookstoves compared to control followed a similar trend for SDNN, the greatest effect was seen immediately following three stone fire (β = −0.13 ms {%}; 95% confidence interval = −0.22, −0.03%), which reversed in direction at 3 h (0.03%; −0.06, 0.13%). VLF results were similar in direction and timing to SDNN; however, other HRV or cardiac repolarization results were not similar to those for SDNN. Discussion: We observed some evidence of short-term, effects on HRV immediately following cookstove treatments compared to control. Our results suggest that cookstoves with lower PM2.5 emissions are potentially capable of affecting cardiac function, similar to stoves emitting higher PM2.5 emissions. |
topic |
Cookstove Fine particulate matter Household air pollution Healthy adult Heart rate variability Cardiac repolarization |
url |
http://www.sciencedirect.com/science/article/pii/S0160412020322091 |
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doaj-8ebf2992053c47d2b8ef3756c17e654d2020-12-27T04:27:51ZengElsevierEnvironment International0160-41202021-01-01146106254Short-term differences in cardiac function following controlled exposure to cookstove air pollution: The subclinical tests on volunteers exposed to smoke (STOVES) studyTom Cole-Hunter0Radhika Dhingra1Kristen M. Fedak2Nicholas Good3Christian L'Orange4Gary Luckasen5John Mehaffy6Ethan Walker7Ander Wilson8John Balmes9Robert D. Brook10Maggie L. Clark11Robert B. Devlin12John Volckens13Jennifer L. Peel14Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Centre for Air Pollution, Energy, and Health Research, University of New South Wales, Sydney, NSW, Australia; International Laboratory for Air Quality and Health, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD, Australia; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Environmental Sciences and Engineering, University of North Carolina, NC, USA; Environmental Public Health Division, United States Environmental Protection Agency, Chapel Hill, NC, USADepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USADepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USADepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, USAHeart Center of the Rockies, Fort Collins, CO, USADepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, USADepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USADepartment of Statistics, Colorado State University, Fort Collins, CO, USADepartment of Medicine, University of California, San Francisco, CA, USADivision of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USAEnvironmental Public Health Division, United States Environmental Protection Agency, Chapel Hill, NC, USADepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USADepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Corresponding author at: Post: 1681 Campus Delivery, Fort Collins, CO 80523-1681, USA.Background: Exposure to household air pollution from solid fuel combustion for cooking and heating is an important risk factor for premature death and disability worldwide. Current evidence supports an association of ambient air pollution with cardiovascular disease but is limited for household air pollution and for cardiac function. Controlled exposure studies can complement evidence provided by field studies. Objectives: To investigate effects of short-term, controlled exposures to emissions from five cookstoves on measures of cardiac function. Methods: Forty-eight healthy adults (46% female; 20–36 years) participated in six, 2-h exposures (‘treatments’), including emissions from five cookstoves and a filtered-air control. Target fine particulate matter (PM2.5) exposure-concentrations per treatment were: control, 0 µg/m3; liquefied petroleum gas, 10 µg/m3; gasifier, 35 µg/m3; fan rocket, 100 µg/m3; rocket elbow, 250 µg/m3; and three stone fire, 500 µg/m3. Participants were treated in a set (pre-randomized) sequence as groups of 4 to minimize order bias and time-varying confounders. Heart rate variability (HRV) and cardiac repolarization metrics were calculated as 5-min means immediately and at 3 h following treatment, for analysis in linear mixed-effects models comparing cookstove to control. Results: Short-term differences in SDNN (standard deviation of duration of all NN intervals) and VLF (very-low frequency power) existed for several cookstoves compared to control. While all cookstoves compared to control followed a similar trend for SDNN, the greatest effect was seen immediately following three stone fire (β = −0.13 ms {%}; 95% confidence interval = −0.22, −0.03%), which reversed in direction at 3 h (0.03%; −0.06, 0.13%). VLF results were similar in direction and timing to SDNN; however, other HRV or cardiac repolarization results were not similar to those for SDNN. Discussion: We observed some evidence of short-term, effects on HRV immediately following cookstove treatments compared to control. Our results suggest that cookstoves with lower PM2.5 emissions are potentially capable of affecting cardiac function, similar to stoves emitting higher PM2.5 emissions.http://www.sciencedirect.com/science/article/pii/S0160412020322091CookstoveFine particulate matterHousehold air pollutionHealthy adultHeart rate variabilityCardiac repolarization |