Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy
In patients with atherosclerotic stenosis of the extracranial segment of internal carotid artery, surgical intervention is an effective method to prevent cerebral ischemic stroke. However, this surgical procedure may cause vascular brain damage. The aim of the study was to investigate consequential...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2016-01-01
|
Series: | Acta Clinica Croatica |
Subjects: | |
Online Access: | http://hrcak.srce.hr/file/262239 |
id |
doaj-8ec35a1572c34a76a04f4871dc6a6e71 |
---|---|
record_format |
Article |
spelling |
doaj-8ec35a1572c34a76a04f4871dc6a6e712020-11-24T23:25:32ZengSestre Milosrdnice University hospital, Institute of Clinical Medical Research Acta Clinica Croatica0353-94661333-94512016-01-01554.579583Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomyMarek Iłżecki0Joanna Iłżecka1Stanisław Przywara2Aneta Grabarska3Tomasz Zubilewicz4Piotr Terlecki5Andrzej Stepulak6Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, PolandIndepondent Neurological Rehabilitation Unit, Medical University of Lublin, Lublin, PolandChair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, PolandChair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, PolandChair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, PolandChair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, PolandChair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, PolandIn patients with atherosclerotic stenosis of the extracranial segment of internal carotid artery, surgical intervention is an effective method to prevent cerebral ischemic stroke. However, this surgical procedure may cause vascular brain damage. The aim of the study was to investigate consequential brain ischemia-reperfusion injury by measuring the cerebral specific marker, neuronspecific enolase (NSE), in serum of patients having undergone internal carotid endarterectomy (CEA). The study involved 25 patients that underwent CEA due to internal carotid artery stenosis. Blood samples were obtained from each patient on three occasions: within 24 h prior to surgery, 12 h after surgery, and 48 h after surgery. Serum NSE levels were measured by a commercially available enzymelinked immunosorbent assay. The study showed that serum NSE level was statistically significantly increased 48 h after CEA as compared with the level 12 h after surgery and the level before surgery (p<0.05). Difference in serum NSE between the level before surgery and 12 h after CEA was not statistically significant (p>0.05). Data from our study showed CEA to affect serum NSE in patients with significant internal carotid artery stenosis. Thus, serum NSE may be used as a biochemical marker of brain ischemia-reperfusion injury following CEA.http://hrcak.srce.hr/file/262239Carotid endarterectomyIschemic strokeNeuron-specific enolase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marek Iłżecki Joanna Iłżecka Stanisław Przywara Aneta Grabarska Tomasz Zubilewicz Piotr Terlecki Andrzej Stepulak |
spellingShingle |
Marek Iłżecki Joanna Iłżecka Stanisław Przywara Aneta Grabarska Tomasz Zubilewicz Piotr Terlecki Andrzej Stepulak Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy Acta Clinica Croatica Carotid endarterectomy Ischemic stroke Neuron-specific enolase |
author_facet |
Marek Iłżecki Joanna Iłżecka Stanisław Przywara Aneta Grabarska Tomasz Zubilewicz Piotr Terlecki Andrzej Stepulak |
author_sort |
Marek Iłżecki |
title |
Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_short |
Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_full |
Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_fullStr |
Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_full_unstemmed |
Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
title_sort |
serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy |
publisher |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
series |
Acta Clinica Croatica |
issn |
0353-9466 1333-9451 |
publishDate |
2016-01-01 |
description |
In patients with atherosclerotic stenosis of the extracranial segment of internal carotid artery, surgical intervention is an effective method to prevent cerebral ischemic stroke. However, this surgical procedure may cause vascular brain damage. The aim of the study was to investigate consequential brain ischemia-reperfusion injury by measuring the cerebral specific marker, neuronspecific enolase (NSE), in serum of patients having undergone internal carotid endarterectomy (CEA). The study involved 25 patients that underwent CEA due to internal carotid artery stenosis. Blood samples were obtained from each patient on three occasions: within 24 h prior to surgery, 12 h after surgery, and 48 h after surgery. Serum NSE levels were measured by a commercially available enzymelinked immunosorbent assay. The study showed that serum NSE level was statistically significantly increased 48 h after CEA as compared with the level 12 h after surgery and the level before surgery (p<0.05). Difference in serum NSE between the level before surgery and 12 h after CEA was not statistically significant (p>0.05). Data from our study showed CEA to affect serum NSE in patients with significant internal carotid artery stenosis. Thus, serum NSE may be used as a biochemical marker of brain ischemia-reperfusion injury following CEA. |
topic |
Carotid endarterectomy Ischemic stroke Neuron-specific enolase |
url |
http://hrcak.srce.hr/file/262239 |
work_keys_str_mv |
AT marekiłzecki serumneuronspecificenolaseasamarkerofbrainischemiareperfusioninjuryinpatientsundergoingcarotidendarterectomy AT joannaiłzecka serumneuronspecificenolaseasamarkerofbrainischemiareperfusioninjuryinpatientsundergoingcarotidendarterectomy AT stanisławprzywara serumneuronspecificenolaseasamarkerofbrainischemiareperfusioninjuryinpatientsundergoingcarotidendarterectomy AT anetagrabarska serumneuronspecificenolaseasamarkerofbrainischemiareperfusioninjuryinpatientsundergoingcarotidendarterectomy AT tomaszzubilewicz serumneuronspecificenolaseasamarkerofbrainischemiareperfusioninjuryinpatientsundergoingcarotidendarterectomy AT piotrterlecki serumneuronspecificenolaseasamarkerofbrainischemiareperfusioninjuryinpatientsundergoingcarotidendarterectomy AT andrzejstepulak serumneuronspecificenolaseasamarkerofbrainischemiareperfusioninjuryinpatientsundergoingcarotidendarterectomy |
_version_ |
1725557020318236672 |