Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea
Background Only a few studies have established the epidemiology of prolactinoma and Cushing’s disease in Korea. Furthermore, the incidence of these disease are increasing than before associated with the development of technologies. This study was designed to evaluate the epidemiology of prolactinoma...
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doaj-8ec93c1636594a41ace748027dc779742021-07-05T06:12:46ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782021-06-0136368869610.3803/EnM.2021.10002189Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in KoreaJin Sun Park0Soo Jin Yun1Jung Kuk Lee2So Young Park3Sang Ouk Chin4 Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea Department of Biostatistics, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, KoreaBackground Only a few studies have established the epidemiology of prolactinoma and Cushing’s disease in Korea. Furthermore, the incidence of these disease are increasing than before associated with the development of technologies. This study was designed to evaluate the epidemiology of prolactinoma and Cushing’s disease and their survival analysis according to treatment. Methods The nationwide, population-based study evaluated incidence and prevalence of prolactinoma and Cushing’s disease using de-identified claims data in The Korean Health Insurance Review and Assessment Service database between 2013 and 2017. The survival analysis investigated regarding treatment over a period of 6 years. A log-rank test and Cox proportional hazard regression analysis were used. Results The 6,056 patients with newly diagnosed prolactinoma and 584 patients with Cushing’s disease were recorded between 2013 and 2017. The annual incidence of prolactinoma was 23.5 cases per million, and its prevalence was 82.5 cases per million, and 2.3 cases per million/year and 9.8 cases per million for Cushing’s disease. The survival benefit was insignificant in prolactinoma according to treatment, but treatment of Cushing’s disease ameliorated the survival rate significantly. Conclusion Overall, the incidence of prolactinoma and Cushing’s disease was similar with those found previously, but the prevalence of two diseases were inconsistent when compared with the early studies. The present study also proposed necessity of treatment in Cushing’s disease for improving the survival rate.http://www.e-enm.org/upload/pdf/enm-2021-1000.pdfprolactinomapituitary acth hypersecretionincidenceprevalencesurvival analysisepidemiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jin Sun Park Soo Jin Yun Jung Kuk Lee So Young Park Sang Ouk Chin |
spellingShingle |
Jin Sun Park Soo Jin Yun Jung Kuk Lee So Young Park Sang Ouk Chin Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea Endocrinology and Metabolism prolactinoma pituitary acth hypersecretion incidence prevalence survival analysis epidemiology |
author_facet |
Jin Sun Park Soo Jin Yun Jung Kuk Lee So Young Park Sang Ouk Chin |
author_sort |
Jin Sun Park |
title |
Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea |
title_short |
Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea |
title_full |
Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea |
title_fullStr |
Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea |
title_full_unstemmed |
Descriptive Epidemiology and Survival Analysis of Prolactinomas and Cushing’s Disease in Korea |
title_sort |
descriptive epidemiology and survival analysis of prolactinomas and cushing’s disease in korea |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2021-06-01 |
description |
Background Only a few studies have established the epidemiology of prolactinoma and Cushing’s disease in Korea. Furthermore, the incidence of these disease are increasing than before associated with the development of technologies. This study was designed to evaluate the epidemiology of prolactinoma and Cushing’s disease and their survival analysis according to treatment. Methods The nationwide, population-based study evaluated incidence and prevalence of prolactinoma and Cushing’s disease using de-identified claims data in The Korean Health Insurance Review and Assessment Service database between 2013 and 2017. The survival analysis investigated regarding treatment over a period of 6 years. A log-rank test and Cox proportional hazard regression analysis were used. Results The 6,056 patients with newly diagnosed prolactinoma and 584 patients with Cushing’s disease were recorded between 2013 and 2017. The annual incidence of prolactinoma was 23.5 cases per million, and its prevalence was 82.5 cases per million, and 2.3 cases per million/year and 9.8 cases per million for Cushing’s disease. The survival benefit was insignificant in prolactinoma according to treatment, but treatment of Cushing’s disease ameliorated the survival rate significantly. Conclusion Overall, the incidence of prolactinoma and Cushing’s disease was similar with those found previously, but the prevalence of two diseases were inconsistent when compared with the early studies. The present study also proposed necessity of treatment in Cushing’s disease for improving the survival rate. |
topic |
prolactinoma pituitary acth hypersecretion incidence prevalence survival analysis epidemiology |
url |
http://www.e-enm.org/upload/pdf/enm-2021-1000.pdf |
work_keys_str_mv |
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