State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder
BackgroundEven with continuous antidepressant treatment, residual symptoms and the risk of relapse can persist in remitted major depressive disorder (MDD) patients. Hence, having a clear recognition of the persistent abnormalities of the underlying neural substrate in MDD through a longitudinal inve...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00431/full |
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doaj-8ed7f5b08017463c81fcc06f06bd21c5 |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Qiangli Dong Qiangli Dong Jin Liu Jin Liu Lingli Zeng Yiming Fan Xiaowen Lu Xiaowen Lu Jinrong Sun Jinrong Sun Liang Zhang Liang Zhang Mi Wang Mi Wang Hua Guo Futao Zhao Danfeng Yan Danfeng Yan Haolun Li Haolun Li Weilong Guo Weilong Guo Yan Zhang Yan Zhang Bangshan Liu Bangshan Liu Dewen Hu Lingjiang Li Lingjiang Li |
| spellingShingle |
Qiangli Dong Qiangli Dong Jin Liu Jin Liu Lingli Zeng Yiming Fan Xiaowen Lu Xiaowen Lu Jinrong Sun Jinrong Sun Liang Zhang Liang Zhang Mi Wang Mi Wang Hua Guo Futao Zhao Danfeng Yan Danfeng Yan Haolun Li Haolun Li Weilong Guo Weilong Guo Yan Zhang Yan Zhang Bangshan Liu Bangshan Liu Dewen Hu Lingjiang Li Lingjiang Li State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder Frontiers in Psychiatry major depressive disorder diffusion tensor imaging white matter microstructure fractional anisotropy state-independent |
| author_facet |
Qiangli Dong Qiangli Dong Jin Liu Jin Liu Lingli Zeng Yiming Fan Xiaowen Lu Xiaowen Lu Jinrong Sun Jinrong Sun Liang Zhang Liang Zhang Mi Wang Mi Wang Hua Guo Futao Zhao Danfeng Yan Danfeng Yan Haolun Li Haolun Li Weilong Guo Weilong Guo Yan Zhang Yan Zhang Bangshan Liu Bangshan Liu Dewen Hu Lingjiang Li Lingjiang Li |
| author_sort |
Qiangli Dong |
| title |
State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder |
| title_short |
State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder |
| title_full |
State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder |
| title_fullStr |
State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder |
| title_full_unstemmed |
State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder |
| title_sort |
state-independent microstructural white matter abnormalities in major depressive disorder |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Psychiatry |
| issn |
1664-0640 |
| publishDate |
2020-05-01 |
| description |
BackgroundEven with continuous antidepressant treatment, residual symptoms and the risk of relapse can persist in remitted major depressive disorder (MDD) patients. Hence, having a clear recognition of the persistent abnormalities of the underlying neural substrate in MDD through a longitudinal investigation is of great importance.MethodsA total of 127 adult medication-free MDD patients with an acute depressive episode and 118 matched healthy controls (HCs) underwent diffusion tensor imaging. Over a 6-month treatment course, 62 remitted patients underwent a second scan. Remission was defined as a 24-item Hamilton Depression Rating Scale (HAMD24) score ≤7 for at least two weeks. Diffusion tensor imaging was performed with a 3.0 T scanner. Differences in whole-brain fractional anisotropy (FA) between MDD patients and HCs were assessed by an independent t-test using gender, age, and education as covariates.ResultsSignificant FA reductions in the left insula, left middle occipital gyrus, right thalamus, left pallidum and left precuneus were observed in current MDD (cMDD) patients compared with HCs. Moreover, significant FA reductions in the left insula were observed in remitted (rMDD) patients compared to HCs. However, no significant differences in FA values were found when comparing cMDD and rMDD patients.ConclusionsThe abnormalities in the insula showed state-independent characteristics, while the abnormalities in the middle occipital gyrus, thalamus, pallidum and precuneus seemed to be state-dependent impairments in MDD patients. |
| topic |
major depressive disorder diffusion tensor imaging white matter microstructure fractional anisotropy state-independent |
| url |
https://www.frontiersin.org/article/10.3389/fpsyt.2020.00431/full |
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doaj-8ed7f5b08017463c81fcc06f06bd21c52020-11-25T02:20:54ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-05-011110.3389/fpsyt.2020.00431528419State-Independent Microstructural White Matter Abnormalities in Major Depressive DisorderQiangli Dong0Qiangli Dong1Jin Liu2Jin Liu3Lingli Zeng4Yiming Fan5Xiaowen Lu6Xiaowen Lu7Jinrong Sun8Jinrong Sun9Liang Zhang10Liang Zhang11Mi Wang12Mi Wang13Hua Guo14Futao Zhao15Danfeng Yan16Danfeng Yan17Haolun Li18Haolun Li19Weilong Guo20Weilong Guo21Yan Zhang22Yan Zhang23Bangshan Liu24Bangshan Liu25Dewen Hu26Lingjiang Li27Lingjiang Li28Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, ChinaCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, Zhumadian Psychiatric Hospital, Zhumadian, ChinaDepartment of Psychiatry, Zhumadian Psychiatric Hospital, Zhumadian, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaBackgroundEven with continuous antidepressant treatment, residual symptoms and the risk of relapse can persist in remitted major depressive disorder (MDD) patients. Hence, having a clear recognition of the persistent abnormalities of the underlying neural substrate in MDD through a longitudinal investigation is of great importance.MethodsA total of 127 adult medication-free MDD patients with an acute depressive episode and 118 matched healthy controls (HCs) underwent diffusion tensor imaging. Over a 6-month treatment course, 62 remitted patients underwent a second scan. Remission was defined as a 24-item Hamilton Depression Rating Scale (HAMD24) score ≤7 for at least two weeks. Diffusion tensor imaging was performed with a 3.0 T scanner. Differences in whole-brain fractional anisotropy (FA) between MDD patients and HCs were assessed by an independent t-test using gender, age, and education as covariates.ResultsSignificant FA reductions in the left insula, left middle occipital gyrus, right thalamus, left pallidum and left precuneus were observed in current MDD (cMDD) patients compared with HCs. Moreover, significant FA reductions in the left insula were observed in remitted (rMDD) patients compared to HCs. However, no significant differences in FA values were found when comparing cMDD and rMDD patients.ConclusionsThe abnormalities in the insula showed state-independent characteristics, while the abnormalities in the middle occipital gyrus, thalamus, pallidum and precuneus seemed to be state-dependent impairments in MDD patients.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00431/fullmajor depressive disorderdiffusion tensor imagingwhite matter microstructurefractional anisotropystate-independent |