Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers
Background: Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation that has shown to be effective in treatment-resistant depression. Through studying the effect of iTBS on healthy subjects, we wished to attain a greater understanding of its impact on th...
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doaj-8ed98d517ad24bf584eebe0fd4453fa12021-06-30T23:00:09ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-01102449244910.3390/jcm10112449Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy VolunteersVirginie Moulier0Christian Gaudeau-Bosma1Fanny Thomas2Clémence Isaac3Maxence Thomas4Florence Durand5Palmyre Schenin-King Andrianisaina6Romain Valabregue7Charles Laidi8René Benadhira9Noomane Bouaziz10Dominique Januel11Unité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceEspace Territoriale d’Accompagnement Psychosociale, CH Les Murets, GHT94, 94120 Fontenay sous Bois, FranceUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceInstitut du Cerveau et de la Moelle Épinière—ICM, Sorbonne Universités, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, 75013 Paris, FrancePôle de Psychiatrie, Assistance Publique-Hôpitaux de Paris (AP-HP), Faculté de Médecine de Créteil, DMU IMPACT, Hôpitaux Universitaires Mondor, 94028 Créteil, FranceUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceUnité de Recherche Clinique, EPS Ville-Evrard, 93332 Neuilly-sur-Marne, FranceBackground: Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation that has shown to be effective in treatment-resistant depression. Through studying the effect of iTBS on healthy subjects, we wished to attain a greater understanding of its impact on the brain. Our objective was to assess whether 10 iTBS sessions altered the neural processing of emotional stimuli, mood and brain anatomy in healthy subjects. Methods: In this double-blind randomized sham-controlled study, 30 subjects received either active iTBS treatment (10 sessions, two sessions a day) or sham treatment over the left dorsolateral prefrontal cortex. Assessments of mood, structural magnetic resonance imaging (MRI) and functional MRI (fMRI) were performed before and after iTBS sessions. During the fMRI, three different categories of stimuli were presented: positive, negative and neutral photographs. Results: This study showed that, during the presentation of negative stimuli (compared with neutral stimuli), 10 sessions of iTBS increased activity in the left anterior insula. However, iTBS did not induce any change in mood, regional gray matter volume or cortical thickness. Conclusions: iTBS modifies healthy subjects’ brain activity in a key region that processes emotional stimuli. (AFSSAPS: ID-RCB 2010A01032-37).https://www.mdpi.com/2077-0383/10/11/2449iTBSrTMSemotionbrainhealthy subjects |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Virginie Moulier Christian Gaudeau-Bosma Fanny Thomas Clémence Isaac Maxence Thomas Florence Durand Palmyre Schenin-King Andrianisaina Romain Valabregue Charles Laidi René Benadhira Noomane Bouaziz Dominique Januel |
spellingShingle |
Virginie Moulier Christian Gaudeau-Bosma Fanny Thomas Clémence Isaac Maxence Thomas Florence Durand Palmyre Schenin-King Andrianisaina Romain Valabregue Charles Laidi René Benadhira Noomane Bouaziz Dominique Januel Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers Journal of Clinical Medicine iTBS rTMS emotion brain healthy subjects |
author_facet |
Virginie Moulier Christian Gaudeau-Bosma Fanny Thomas Clémence Isaac Maxence Thomas Florence Durand Palmyre Schenin-King Andrianisaina Romain Valabregue Charles Laidi René Benadhira Noomane Bouaziz Dominique Januel |
author_sort |
Virginie Moulier |
title |
Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers |
title_short |
Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers |
title_full |
Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers |
title_fullStr |
Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers |
title_full_unstemmed |
Effect of Intermittent Theta Burst Stimulation on the Neural Processing of Emotional Stimuli in Healthy Volunteers |
title_sort |
effect of intermittent theta burst stimulation on the neural processing of emotional stimuli in healthy volunteers |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-06-01 |
description |
Background: Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation that has shown to be effective in treatment-resistant depression. Through studying the effect of iTBS on healthy subjects, we wished to attain a greater understanding of its impact on the brain. Our objective was to assess whether 10 iTBS sessions altered the neural processing of emotional stimuli, mood and brain anatomy in healthy subjects. Methods: In this double-blind randomized sham-controlled study, 30 subjects received either active iTBS treatment (10 sessions, two sessions a day) or sham treatment over the left dorsolateral prefrontal cortex. Assessments of mood, structural magnetic resonance imaging (MRI) and functional MRI (fMRI) were performed before and after iTBS sessions. During the fMRI, three different categories of stimuli were presented: positive, negative and neutral photographs. Results: This study showed that, during the presentation of negative stimuli (compared with neutral stimuli), 10 sessions of iTBS increased activity in the left anterior insula. However, iTBS did not induce any change in mood, regional gray matter volume or cortical thickness. Conclusions: iTBS modifies healthy subjects’ brain activity in a key region that processes emotional stimuli. (AFSSAPS: ID-RCB 2010A01032-37). |
topic |
iTBS rTMS emotion brain healthy subjects |
url |
https://www.mdpi.com/2077-0383/10/11/2449 |
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