Ellagic acid inhibits melanoma growth in vitro
Ellagic is a polyphenolic compound with anti-fibrotic and antioxidant properties as well as exhibits antitumor properties against various cancer cells <em>in vitro</em>. There are few studies, however, which examine the effects of ellagic acid on melanoma. In the present study, we obser...
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doaj-8edc0e403a1c41f690763ed5291bd4c92020-11-25T03:50:51ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062011-12-0133e36e3610.4081/dr.2011.e361857Ellagic acid inhibits melanoma growth in vitroJames Daniel Jensen0Jeffrey H. Dunn1Yuchun Luo2Weimin Liu3Mayumi Fujita4Robert P. Dellavalle5Department of Dermatology, School of Medicine, University of Colorado, Denver, CODepartment of Dermatology, School of Medicine, University of Colorado, Denver, CODepartment of Dermatology, School of Medicine, University of Colorado, Denver, CODepartment of Dermatology, School of Medicine, University of Colorado, Denver, CODepartment of Dermatology, School of Medicine, University of Colorado, Denver; Denver Veterans's Affairs Medical Center, Denver, CODepartment of Dermatology, School of Medicine, University of Colorado, Denver; Denver Veterans's Affairs Medical Center, Denver, COEllagic is a polyphenolic compound with anti-fibrotic and antioxidant properties as well as exhibits antitumor properties against various cancer cells <em>in vitro</em>. There are few studies, however, which examine the effects of ellagic acid on melanoma. In the present study, we observe effects of ellagic acid on melanoma cells <em>in vitro</em>. Three metastatic melanoma cell lines (1205Lu, WM852c and A375) were examined to determine the effects of ellagic acid on melanoma cell viability, cell-cycle, apoptosis, NF-κβ activity, and IL-1β & IL-8 secretion. Cell viability assays demonstrated that ellagic acid possesses an inhibitory effect on cell proliferation at concentrations between 25 and 100 µM. In addition, ellagic acid promoted G1 cell cycle arrest, increased levels of apoptosis and decreased synthesis of IL-1β and IL-8 in melanoma cells. Ellagic acid also decreased NF-κβ activity, suggesting at least one potential mechanism by which ellagic acid may exert its effects in melanoma cells. Our findings support further investigation into prospective roles for ellagic acid as a therapeutic, adjuvant, or preventive agent for melanoma.http://www.pagepress.org/journals/index.php/dr/article/view/3351ellagic acid, melanoma, NF-κB, IL-1β, IL-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
James Daniel Jensen Jeffrey H. Dunn Yuchun Luo Weimin Liu Mayumi Fujita Robert P. Dellavalle |
spellingShingle |
James Daniel Jensen Jeffrey H. Dunn Yuchun Luo Weimin Liu Mayumi Fujita Robert P. Dellavalle Ellagic acid inhibits melanoma growth in vitro Dermatology Reports ellagic acid, melanoma, NF-κB, IL-1β, IL-8 |
author_facet |
James Daniel Jensen Jeffrey H. Dunn Yuchun Luo Weimin Liu Mayumi Fujita Robert P. Dellavalle |
author_sort |
James Daniel Jensen |
title |
Ellagic acid inhibits melanoma growth in vitro |
title_short |
Ellagic acid inhibits melanoma growth in vitro |
title_full |
Ellagic acid inhibits melanoma growth in vitro |
title_fullStr |
Ellagic acid inhibits melanoma growth in vitro |
title_full_unstemmed |
Ellagic acid inhibits melanoma growth in vitro |
title_sort |
ellagic acid inhibits melanoma growth in vitro |
publisher |
PAGEPress Publications |
series |
Dermatology Reports |
issn |
2036-7392 2036-7406 |
publishDate |
2011-12-01 |
description |
Ellagic is a polyphenolic compound with anti-fibrotic and antioxidant properties as well as exhibits antitumor properties against various cancer cells <em>in vitro</em>. There are few studies, however, which examine the effects of ellagic acid on melanoma. In the present study, we observe effects of ellagic acid on melanoma cells <em>in vitro</em>. Three metastatic melanoma cell lines (1205Lu, WM852c and A375) were examined to determine the effects of ellagic acid on melanoma cell viability, cell-cycle, apoptosis, NF-κβ activity, and IL-1β & IL-8 secretion. Cell viability assays demonstrated that ellagic acid possesses an inhibitory effect on cell proliferation at concentrations between 25 and 100 µM. In addition, ellagic acid promoted G1 cell cycle arrest, increased levels of apoptosis and decreased synthesis of IL-1β and IL-8 in melanoma cells. Ellagic acid also decreased NF-κβ activity, suggesting at least one potential mechanism by which ellagic acid may exert its effects in melanoma cells. Our findings support further investigation into prospective roles for ellagic acid as a therapeutic, adjuvant, or preventive agent for melanoma. |
topic |
ellagic acid, melanoma, NF-κB, IL-1β, IL-8 |
url |
http://www.pagepress.org/journals/index.php/dr/article/view/3351 |
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