Analysis of the Correlation between Molecular Structural Differences of PD-1/PD-L1 Inhibitors and Adverse Events

• Main Authors: Tongji XIE, Shouzheng WANG, Puyuan XING
• Format: Article
• Language: zho
• Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2020-07-01
• Series: Chinese Journal of Lung Cancer
• Subjects: programmed cell death protein 1; programmed cell death ligand 1; structure; adverse events
• Online Access: http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.17
• ISSN: 1009-3419; 1999-6187

As a new method, immunotherapy which is targeting programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) plays a more and more important role in the treatment of malignant tumors. Immunotherapy is more effective than traditional chemotherapy. However, there are also many adverse events during the application of immunocheckpoint inhibitors targeting PD-1/PD-L1, and the incidence rate of these adverse events among different drugs is different. Because the molecular structure of these drugs is an important indicator to distinguish them, this paper will analyze the correlation between molecular structure and adverse events of PD-1/PD-L1 immunocheckpoint inhibitors through reviewing some meta-analyses and retrospective analyses from the perspective of different structures.