Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces. Since in vivo validation is not possible for the h...

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Bibliographic Details
Main Authors: Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
mammalian Embryo
epiblast
gastrulation
pluripotent stem cells
micropatterns
Online Access:https://elifesciences.org/articles/32839

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