Anti-Idiotype scFv Localizes an Autoepitope in the Globular Domain of C1q

Anti-Idiotype scFv Localizes an Autoepitope in the Globular Domain of C1q

We addressed the issue of C1q autoantigenicity by studying the structural features of the autoepitopes recognized by the polyclonal anti-C1q antibodies present in Lupus Nephritis (LN) sera. We used six fractions of anti-C1q as antigens and selected anti-idiotypic scFv antibodies from the phage libra...

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Bibliographic Details
Main Authors: Nadezhda Todorova, Miroslav Rangelov, Vanya Bogoeva, Vishnya Stoyanova, Anna Yordanova, Ginka Nikolova, Hristo Georgiev, Daniela Dimitrova, Safa Mohedin, Katerina Stoyanova, Ivanka Tsacheva
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
C1q
globular autoepitopes
scFv
anti-DNA
Online Access:https://www.mdpi.com/1422-0067/22/15/8288

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