MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1
Abstract The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpressi...
Main Authors: | , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-01-01
|
Series: | Journal of Hematology & Oncology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13045-017-0402-6 |
id |
doaj-8ef5535edf8a4ebda4500ab32d5169c3 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pei Li Yang Yang Hui Liu An-Kui Yang Jin-Ming Di Guang-Mou Tan Hai-Feng Wang Jian-Ge Qiu Wen-Ji Zhang Qi-Wei Jiang Di-Wei Zheng Yao Chen Meng-Ning Wei Jia-Rong Huang Kun Wang Zhi Shi Jin Ye |
spellingShingle |
Pei Li Yang Yang Hui Liu An-Kui Yang Jin-Ming Di Guang-Mou Tan Hai-Feng Wang Jian-Ge Qiu Wen-Ji Zhang Qi-Wei Jiang Di-Wei Zheng Yao Chen Meng-Ning Wei Jia-Rong Huang Kun Wang Zhi Shi Jin Ye MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1 Journal of Hematology & Oncology Laryngeal squamous cell carcinoma miR-194 Wee1 |
author_facet |
Pei Li Yang Yang Hui Liu An-Kui Yang Jin-Ming Di Guang-Mou Tan Hai-Feng Wang Jian-Ge Qiu Wen-Ji Zhang Qi-Wei Jiang Di-Wei Zheng Yao Chen Meng-Ning Wei Jia-Rong Huang Kun Wang Zhi Shi Jin Ye |
author_sort |
Pei Li |
title |
MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1 |
title_short |
MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1 |
title_full |
MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1 |
title_fullStr |
MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1 |
title_full_unstemmed |
MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1 |
title_sort |
mir-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting wee1 |
publisher |
BMC |
series |
Journal of Hematology & Oncology |
issn |
1756-8722 |
publishDate |
2017-01-01 |
description |
Abstract The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits the proliferation, migration, invasion, and drug resistance in LSCC cells. Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 on the malignant phenotypes of LSCC. Overall, our study provides new sights into the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based clinical application for LSCC patients. |
topic |
Laryngeal squamous cell carcinoma miR-194 Wee1 |
url |
http://link.springer.com/article/10.1186/s13045-017-0402-6 |
work_keys_str_mv |
AT peili mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT yangyang mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT huiliu mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT ankuiyang mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT jinmingdi mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT guangmoutan mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT haifengwang mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT jiangeqiu mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT wenjizhang mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT qiweijiang mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT diweizheng mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT yaochen mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT mengningwei mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT jiaronghuang mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT kunwang mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT zhishi mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 AT jinye mir194functionsasatumorsuppressorinlaryngealsquamouscellcarcinomabytargetingwee1 |
_version_ |
1724835336687714304 |
spelling |
doaj-8ef5535edf8a4ebda4500ab32d5169c32020-11-25T02:28:57ZengBMCJournal of Hematology & Oncology1756-87222017-01-011011410.1186/s13045-017-0402-6MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1Pei Li0Yang Yang1Hui Liu2An-Kui Yang3Jin-Ming Di4Guang-Mou Tan5Hai-Feng Wang6Jian-Ge Qiu7Wen-Ji Zhang8Qi-Wei Jiang9Di-Wei Zheng10Yao Chen11Meng-Ning Wei12Jia-Rong Huang13Kun Wang14Zhi Shi15Jin Ye16Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDivision of Pulmonary and Critical Care, Department of Internal Medicine, The Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Head and Neck, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Urology, The Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Head & Neck Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan UniversityDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen UniversityAbstract The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits the proliferation, migration, invasion, and drug resistance in LSCC cells. Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 on the malignant phenotypes of LSCC. Overall, our study provides new sights into the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based clinical application for LSCC patients.http://link.springer.com/article/10.1186/s13045-017-0402-6Laryngeal squamous cell carcinomamiR-194Wee1 |