Drug consumption and additional risk factors associated with microscopic colitis: case-control study
Background: Microscopic colitis has now emerged as a common cause of chronic diarrhoea, but its aetiology remains unknown. Some studies suggest that commonly prescribed drugs and other additional risk factors may be triggers. Aims: To evaluate the effects of drug intake and other risk factors on mic...
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doaj-8ef5cda63fac4adda2b7590344d05f672020-11-24T23:04:57ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082015-06-011076347353S1130-01082015000600004Drug consumption and additional risk factors associated with microscopic colitis: case-control studyDanila Guagnozzi0Alfredo J. Lucendo1Teresa Angueira2Sonia González-Castillo3José María Tenias4Hospital General de TomellosoHospital General de TomellosoHospital General de TomellosoHospital General de TomellosoHospital General La Mancha CentroBackground: Microscopic colitis has now emerged as a common cause of chronic diarrhoea, but its aetiology remains unknown. Some studies suggest that commonly prescribed drugs and other additional risk factors may be triggers. Aims: To evaluate the effects of drug intake and other risk factors on microscopic colitis patients. Methods: A prospective, case-control study with all consecutive adult patients referred to the Hospital General de Tomelloso (Ciudad Real, Spain) for chronic watery diarrhoea (from 2008 to 2011) was performed. Microscopic colitis was diagnosed following the commonly accepted histopathological criteria. Results: 46 consecutive new cases of microscopic colitis and 317 chronic diarrhoea controls were recruited. Five independent risk factors significantly associated with microscopic colitis were identified: Abdominal pain (OR 3.25; 95%CI, 1.49-7.08), weight loss (OR 2.67; 95%CI, 1.16-6.15), celiac disease (OR 15.3; 95%CI, 3.70-63.5), topiramate intake (OR 13.6; 95%CI, 1.84-100.8), and older age at diagnosis (OR 1 year increase 1.022; 95%CI, 1.002-1.042). Use of non-steroidal anti-inflammatory drugs was associated with microscopic colitis in the subgroup of patients who fulfilled irritable bowel syndrome criteria (38.5% vs. 10.8%; p < 0.017). Conclusions: Microscopic colitis is associated with autoimmune disease, an increased age at diagnosis, topiramate intake and only in a sub-group of irritable bowel disease patients with non-steroidal anti-inflammatory drugs.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015000600004&lng=en&tlng=enMicroscopic colitisDrug intakeIrritable bowel syndromeChronic diarrhoea |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Danila Guagnozzi Alfredo J. Lucendo Teresa Angueira Sonia González-Castillo José María Tenias |
spellingShingle |
Danila Guagnozzi Alfredo J. Lucendo Teresa Angueira Sonia González-Castillo José María Tenias Drug consumption and additional risk factors associated with microscopic colitis: case-control study Revista Espanola de Enfermedades Digestivas Microscopic colitis Drug intake Irritable bowel syndrome Chronic diarrhoea |
author_facet |
Danila Guagnozzi Alfredo J. Lucendo Teresa Angueira Sonia González-Castillo José María Tenias |
author_sort |
Danila Guagnozzi |
title |
Drug consumption and additional risk factors associated with microscopic colitis: case-control study |
title_short |
Drug consumption and additional risk factors associated with microscopic colitis: case-control study |
title_full |
Drug consumption and additional risk factors associated with microscopic colitis: case-control study |
title_fullStr |
Drug consumption and additional risk factors associated with microscopic colitis: case-control study |
title_full_unstemmed |
Drug consumption and additional risk factors associated with microscopic colitis: case-control study |
title_sort |
drug consumption and additional risk factors associated with microscopic colitis: case-control study |
publisher |
Aran Ediciones |
series |
Revista Espanola de Enfermedades Digestivas |
issn |
1130-0108 |
publishDate |
2015-06-01 |
description |
Background: Microscopic colitis has now emerged as a common cause of chronic diarrhoea, but its aetiology remains unknown. Some studies suggest that commonly prescribed drugs and other additional risk factors may be triggers. Aims: To evaluate the effects of drug intake and other risk factors on microscopic colitis patients. Methods: A prospective, case-control study with all consecutive adult patients referred to the Hospital General de Tomelloso (Ciudad Real, Spain) for chronic watery diarrhoea (from 2008 to 2011) was performed. Microscopic colitis was diagnosed following the commonly accepted histopathological criteria. Results: 46 consecutive new cases of microscopic colitis and 317 chronic diarrhoea controls were recruited. Five independent risk factors significantly associated with microscopic colitis were identified: Abdominal pain (OR 3.25; 95%CI, 1.49-7.08), weight loss (OR 2.67; 95%CI, 1.16-6.15), celiac disease (OR 15.3; 95%CI, 3.70-63.5), topiramate intake (OR 13.6; 95%CI, 1.84-100.8), and older age at diagnosis (OR 1 year increase 1.022; 95%CI, 1.002-1.042). Use of non-steroidal anti-inflammatory drugs was associated with microscopic colitis in the subgroup of patients who fulfilled irritable bowel syndrome criteria (38.5% vs. 10.8%; p < 0.017). Conclusions: Microscopic colitis is associated with autoimmune disease, an increased age at diagnosis, topiramate intake and only in a sub-group of irritable bowel disease patients with non-steroidal anti-inflammatory drugs. |
topic |
Microscopic colitis Drug intake Irritable bowel syndrome Chronic diarrhoea |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015000600004&lng=en&tlng=en |
work_keys_str_mv |
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