Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy

For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodi...

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Main Authors: Philippe Deloron, Gwladys Bertin, Valérie Briand, Achille Massougbodji, Michel Cot
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2010-11-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/16/11/10-1064_article
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spelling doaj-8ef6a1c078414adbbcc177297a16acc52020-11-24T23:35:30ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592010-11-0116111666167010.3201/eid1611.101064Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during PregnancyPhilippe DeloronGwladys BertinValérie BriandAchille MassougbodjiMichel CotFor monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low birthweights and placental infection rates. In light of this discrepancy, emphasis on using molecular markers for monitoring efficacy of intermittent preventive treatment during pregnancy appears questionable. The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously. Other possible alternative strategies are considered.https://wwwnc.cdc.gov/eid/article/16/11/10-1064_articleMalariapregnancypreventionsulfadoxine/pyrimethamineintermittent preventive treatment in pregnancyparasites
collection DOAJ
language English
format Article
sources DOAJ
author Philippe Deloron
Gwladys Bertin
Valérie Briand
Achille Massougbodji
Michel Cot
spellingShingle Philippe Deloron
Gwladys Bertin
Valérie Briand
Achille Massougbodji
Michel Cot
Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
Emerging Infectious Diseases
Malaria
pregnancy
prevention
sulfadoxine/pyrimethamine
intermittent preventive treatment in pregnancy
parasites
author_facet Philippe Deloron
Gwladys Bertin
Valérie Briand
Achille Massougbodji
Michel Cot
author_sort Philippe Deloron
title Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
title_short Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
title_full Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
title_fullStr Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
title_full_unstemmed Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
title_sort sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2010-11-01
description For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low birthweights and placental infection rates. In light of this discrepancy, emphasis on using molecular markers for monitoring efficacy of intermittent preventive treatment during pregnancy appears questionable. The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously. Other possible alternative strategies are considered.
topic Malaria
pregnancy
prevention
sulfadoxine/pyrimethamine
intermittent preventive treatment in pregnancy
parasites
url https://wwwnc.cdc.gov/eid/article/16/11/10-1064_article
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AT achillemassougbodji sulfadoxinepyrimethamineintermittentpreventivetreatmentformalariaduringpregnancy
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