Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodi...
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Centers for Disease Control and Prevention
2010-11-01
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Online Access: | https://wwwnc.cdc.gov/eid/article/16/11/10-1064_article |
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doaj-8ef6a1c078414adbbcc177297a16acc52020-11-24T23:35:30ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592010-11-0116111666167010.3201/eid1611.101064Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during PregnancyPhilippe DeloronGwladys BertinValérie BriandAchille MassougbodjiMichel CotFor monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low birthweights and placental infection rates. In light of this discrepancy, emphasis on using molecular markers for monitoring efficacy of intermittent preventive treatment during pregnancy appears questionable. The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously. Other possible alternative strategies are considered.https://wwwnc.cdc.gov/eid/article/16/11/10-1064_articleMalariapregnancypreventionsulfadoxine/pyrimethamineintermittent preventive treatment in pregnancyparasites |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Philippe Deloron Gwladys Bertin Valérie Briand Achille Massougbodji Michel Cot |
spellingShingle |
Philippe Deloron Gwladys Bertin Valérie Briand Achille Massougbodji Michel Cot Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy Emerging Infectious Diseases Malaria pregnancy prevention sulfadoxine/pyrimethamine intermittent preventive treatment in pregnancy parasites |
author_facet |
Philippe Deloron Gwladys Bertin Valérie Briand Achille Massougbodji Michel Cot |
author_sort |
Philippe Deloron |
title |
Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy |
title_short |
Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy |
title_full |
Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy |
title_fullStr |
Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy |
title_full_unstemmed |
Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy |
title_sort |
sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2010-11-01 |
description |
For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low birthweights and placental infection rates. In light of this discrepancy, emphasis on using molecular markers for monitoring efficacy of intermittent preventive treatment during pregnancy appears questionable. The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously. Other possible alternative strategies are considered. |
topic |
Malaria pregnancy prevention sulfadoxine/pyrimethamine intermittent preventive treatment in pregnancy parasites |
url |
https://wwwnc.cdc.gov/eid/article/16/11/10-1064_article |
work_keys_str_mv |
AT philippedeloron sulfadoxinepyrimethamineintermittentpreventivetreatmentformalariaduringpregnancy AT gwladysbertin sulfadoxinepyrimethamineintermittentpreventivetreatmentformalariaduringpregnancy AT valeriebriand sulfadoxinepyrimethamineintermittentpreventivetreatmentformalariaduringpregnancy AT achillemassougbodji sulfadoxinepyrimethamineintermittentpreventivetreatmentformalariaduringpregnancy AT michelcot sulfadoxinepyrimethamineintermittentpreventivetreatmentformalariaduringpregnancy |
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1725525892417978368 |