| Summary: | <p>Many factors such as aging, changes in blood electrolytes levels, and possibly family history are involved in senile cataract formation. Changes in serum electrolytes levels can induce changes in aqueous electrolytes levels and effect on lens metabolism and probably cataract formation. In this paper, we study serum level of Na<sup>+ </sup>and K<sup>+</sup> in senile cataract patients and normal individuals. Methods and materials: 155 senile cataract patients scheduled for cataract surgery in eye clinic of Rasoul hospital and 155 normal individuals were selected. Serum Na<sup>+</sup> and K<sup>+</sup> levels were measured by Flame Photometry technique and means compared between two groups by t-test. Results: 1. Mean serum Na<sup>+</sup> level in senile cataract patients and normal individuals was 144.96 ± 6.04 mEq/lit and 140.88 ± 2.27 mEq/lit respectively, and there was statistically significant difference (P<0.0001). 2. Mean serum K<sup>+</sup> level in senile cataract patients and normal individuals was 4.20 ± 0.34 mEq/lit and 4.15 ± 0.32 mEq/lit respectively, and there was no statistically significant difference. Conclusion: Serum Na<sup>+ </sup>level in senile cataract patients was higher than normal individuals in this study. This result might suggest that diets with high Na<sup>+</sup> content are a risk factor for age-related cataract formation, as high Na<sup>+</sup> content of the diet leads to high level of serum Na<sup>+</sup>, which in turn contributes to formation of age-related cataract.</p>
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