Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data

• Main Authors: Dillon PM, Brenin CM, Slingluff CL Jr
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-04-01
• Series: Breast Cancer : Targets and Therapy
• Subjects: vaccine; breast cancer; her2; peptide; human
• Online Access: https://www.dovepress.com/evaluating-nelipepimut-s-in-the-treatment-of-breast-cancer-a-short-rep-peer-reviewed-article-BCTT

Patrick M Dillon,1 Christiana M Brenin,1 Craig L Slingluff Jr2 1University of Virginia, Division of Hematology/Oncology, Charlottesville, VA 22908, USA; 2University of Virginia, Department of Surgery, Charlottesville, VA 22908, USACorrespondence: Patrick M DillonDivision of Hematology/Oncology, University of Virginia, Box 800716, Charlottesville, VA 22908, USATel [phone]Fax [phone]Email [e-mail]: Vaccine therapies for treatment and prevention of cancer have seen modest degrees of efficacy with wide variation related to the tumor type, vaccine type, adjuvants and clinical setting for their study. Over the course of the last two decades, various peptide vaccines for breast cancer have been studied. The current leading peptide vaccine for human application is a HER2-based vaccine known as Nelipepimut-S, which has demonstrated immune activity and promising clinical activity in some settings. This review covers the development of this newer peptide vaccine for both HER2 amplified and non-amplified breast cancer.Keywords: vaccine, breast cancer, HER2, peptide, human