Detection of CD4⁺CD25⁺ regulatory T cell in patients with Graves' ophthalmopathy

• Main Authors: Hai-Bo Xue, Zhao-Dong Han, Lei Zhang, Qiang Wang, Meng Xin
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2013-11-01
• Series: Guoji Yanke Zazhi
• Subjects: Graves' ophthalmopathy; thyroid associated ophthalmopathy; autoimmune; CD4⁺CD25⁺ regulatory T cell
• Online Access: http://www.ies.net.cn/cn_publish/2013/11/201311007.pdf
• ISSN: 1672-5123

AIM: To observe the change law of the ratio of CD4⁺ CD25⁺ regulatory T cell in the peripheral blood of the patients with Graves' ophthalmopathy by detecting the ratio of this cell.<p>METHODS: This experimental study selected 53 GO patients without exophthalmos, 51 GO patients with exophthalmos, and 51 healthy people were collected. The ratio of CD4⁺CD25⁺ T cell in peripheral blood was determined by flow cytometry. <p>RESULTS: The ratio of CD4⁺CD25⁺ T cell in GO patients without exophthalmos was lower than that in healthy group(<i>P</i><0.01). The ratio of CD4⁺CD25⁺ T cell in GO patients with exophthalmos was far lower than that in healthy group(<i>P</i><0.01). Compared with the group of GO patients without exophthalmos, the ratio of CD4⁺ CD25⁺ T cell of GO patients with exophthalmos was also much lower(<i>P</i><0.01). <p>CONCLUSION: The ratio of CD4+ CD25+ T cell in the GO patients decreases and there is autoimmune disorder in patients of this disease. Perhaps this is an important mechanism causing immune suppression damage, which provides a new clue for immunological treatment.