Triapine Radiochemotherapy in Advanced Stage Cervical Cancer
Clinical ribonucleotide reductase (RNR) inhibitors have reinvigorated enthusiasm for radiochemotherapy treatment of patients with regionally advanced stage cervical cancers. About two-thirds of patients outlive their cervical cancer (1), even though up to half of their tumors retain residual microsc...
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Frontiers Media S.A.
2018-05-01
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Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2018.00149/full |
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doaj-8f2f95d88d5b4ef691c1e59acbc316242020-11-24T22:01:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-05-01810.3389/fonc.2018.00149368642Triapine Radiochemotherapy in Advanced Stage Cervical CancerCharles A. KunosS. Percy IvyClinical ribonucleotide reductase (RNR) inhibitors have reinvigorated enthusiasm for radiochemotherapy treatment of patients with regionally advanced stage cervical cancers. About two-thirds of patients outlive their cervical cancer (1), even though up to half of their tumors retain residual microscopic disease (2). The National Cancer Institute Cancer Therapy Evaluation Program conducted two prospective trials of triapine–cisplatin–radiation to improve upon this finding by precisely targeting cervical cancer’s overactive RNR. Triapine’s potent inactivation of RNR arrests cells at the G1/S cell cycle restriction checkpoint and enhances cisplatin–radiation cytotoxicity. In this article, we provide perspective on challenges encountered in and future potential of clinical development of a triapine–cisplatin–radiation combination for patients with regionally advanced cervical cancer. New trial results and review presented here suggest that a triapine–cisplatin–radiation combination may offer molecular cell cycle target control to maximize damage in cancers and to minimize injury to normal cells. A randomized trial now accrues patients with regionally advanced stage cervical cancer to evaluate triapine’s contribution to clinical benefit after cisplatin–radiation (clinicaltrials.gov, NCT02466971).http://journal.frontiersin.org/article/10.3389/fonc.2018.00149/fulltriapinecervical canceruterine cervix cancervaginal cancerradiation therapycisplatin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Charles A. Kunos S. Percy Ivy |
spellingShingle |
Charles A. Kunos S. Percy Ivy Triapine Radiochemotherapy in Advanced Stage Cervical Cancer Frontiers in Oncology triapine cervical cancer uterine cervix cancer vaginal cancer radiation therapy cisplatin |
author_facet |
Charles A. Kunos S. Percy Ivy |
author_sort |
Charles A. Kunos |
title |
Triapine Radiochemotherapy in Advanced Stage Cervical Cancer |
title_short |
Triapine Radiochemotherapy in Advanced Stage Cervical Cancer |
title_full |
Triapine Radiochemotherapy in Advanced Stage Cervical Cancer |
title_fullStr |
Triapine Radiochemotherapy in Advanced Stage Cervical Cancer |
title_full_unstemmed |
Triapine Radiochemotherapy in Advanced Stage Cervical Cancer |
title_sort |
triapine radiochemotherapy in advanced stage cervical cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2018-05-01 |
description |
Clinical ribonucleotide reductase (RNR) inhibitors have reinvigorated enthusiasm for radiochemotherapy treatment of patients with regionally advanced stage cervical cancers. About two-thirds of patients outlive their cervical cancer (1), even though up to half of their tumors retain residual microscopic disease (2). The National Cancer Institute Cancer Therapy Evaluation Program conducted two prospective trials of triapine–cisplatin–radiation to improve upon this finding by precisely targeting cervical cancer’s overactive RNR. Triapine’s potent inactivation of RNR arrests cells at the G1/S cell cycle restriction checkpoint and enhances cisplatin–radiation cytotoxicity. In this article, we provide perspective on challenges encountered in and future potential of clinical development of a triapine–cisplatin–radiation combination for patients with regionally advanced cervical cancer. New trial results and review presented here suggest that a triapine–cisplatin–radiation combination may offer molecular cell cycle target control to maximize damage in cancers and to minimize injury to normal cells. A randomized trial now accrues patients with regionally advanced stage cervical cancer to evaluate triapine’s contribution to clinical benefit after cisplatin–radiation (clinicaltrials.gov, NCT02466971). |
topic |
triapine cervical cancer uterine cervix cancer vaginal cancer radiation therapy cisplatin |
url |
http://journal.frontiersin.org/article/10.3389/fonc.2018.00149/full |
work_keys_str_mv |
AT charlesakunos triapineradiochemotherapyinadvancedstagecervicalcancer AT spercyivy triapineradiochemotherapyinadvancedstagecervicalcancer |
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