Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits
The chloroform and methanol extracts of Opuntia monacantha were studied for its hepatoprotective effect against paracetamol induced liver damage in rabbits. Results proved that both extracts at 200, 400 and 600 mg/kg body weight in one week protocol showed significant (p<0.001) hepatoprotective...
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doaj-8f365d37006f49ba8bdf52ed0cb1c77b2020-11-25T01:13:34ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-01-01101Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbitsMohammad Saleem0Iram Irshad1Muhammad Kashif Baig2Faiza Naseer3College of Pharmacy, GC university FaisalabadCollege of Pharmacy, GC University, Faisalabad, PakistanIndependent Medical College, FaisalabadCollege of Pharmacy, GC university Faisalabad The chloroform and methanol extracts of Opuntia monacantha were studied for its hepatoprotective effect against paracetamol induced liver damage in rabbits. Results proved that both extracts at 200, 400 and 600 mg/kg body weight in one week protocol showed significant (p<0.001) hepatoprotective activity by reducing the magnitude of liver markers including alanine aminotransferase, aspartate aminotransferase, alkaline phasphatase and total bilirubin levels. The results were supported by histopathological studies of liver tissue. Chemical analysis of O. monacantha indicated the presence of alkaloids, tannins, saponins, flavonoids and polysaccharides and its hepato-protective potential may be due to the presence of flavonoids. Its is concluded that 600 mg/kg is the potent dose of both extracts of O. monacantha as hepatoprotective plant. https://www.banglajol.info/index.php/BJP/article/view/20825HepatoprotectiveOpuntia monacanthaParacetamolSilymarin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Saleem Iram Irshad Muhammad Kashif Baig Faiza Naseer |
spellingShingle |
Mohammad Saleem Iram Irshad Muhammad Kashif Baig Faiza Naseer Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits Bangladesh Journal of Pharmacology Hepatoprotective Opuntia monacantha Paracetamol Silymarin |
author_facet |
Mohammad Saleem Iram Irshad Muhammad Kashif Baig Faiza Naseer |
author_sort |
Mohammad Saleem |
title |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits |
title_short |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits |
title_full |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits |
title_fullStr |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits |
title_full_unstemmed |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>Opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits |
title_sort |
evaluation of hepatoprotective effect of chloroform and methanol extracts of <i>opuntia monacantha</i> in paracetamol-induced hepatotoxicity in rabbits |
publisher |
Bangladesh Pharmacological Society |
series |
Bangladesh Journal of Pharmacology |
issn |
1991-0088 |
publishDate |
2015-01-01 |
description |
The chloroform and methanol extracts of Opuntia monacantha were studied for its hepatoprotective effect against paracetamol induced liver damage in rabbits. Results proved that both extracts at 200, 400 and 600 mg/kg body weight in one week protocol showed significant (p<0.001) hepatoprotective activity by reducing the magnitude of liver markers including alanine aminotransferase, aspartate aminotransferase, alkaline phasphatase and total bilirubin levels. The results were supported by histopathological studies of liver tissue. Chemical analysis of O. monacantha indicated the presence of alkaloids, tannins, saponins, flavonoids and polysaccharides and its hepato-protective potential may be due to the presence of flavonoids. Its is concluded that 600 mg/kg is the potent dose of both extracts of O. monacantha as hepatoprotective plant.
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topic |
Hepatoprotective Opuntia monacantha Paracetamol Silymarin |
url |
https://www.banglajol.info/index.php/BJP/article/view/20825 |
work_keys_str_mv |
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