The effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study
Abstract Background To date, there is limited evidence on the effect of antenatal exposure to non-organophosphate household pesticides on infant health. Our hypothesis is that antenatal exposure to non-organophosphate household pesticides will be associated with birth sizes and infant growth rate. M...
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doaj-8f38b7902c694f208c9400383ff301fc2020-11-25T03:01:40ZengBMCBMC Pregnancy and Childbirth1471-23932020-08-012011810.1186/s12884-020-03162-wThe effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort studyFrida Soesanti0Nikmah S. Idris1Kerstin Klipstein-Grobusch2Aryono Hendarto3Diederick E. Grobbee4Cuno S. P. M. Uiterwaal5Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General HospitalDepartment of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General HospitalJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht UniversityDepartment of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General HospitalJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht UniversityJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht UniversityAbstract Background To date, there is limited evidence on the effect of antenatal exposure to non-organophosphate household pesticides on infant health. Our hypothesis is that antenatal exposure to non-organophosphate household pesticides will be associated with birth sizes and infant growth rate. Methods In this prospective cohort study, 284 mother-infant pairs were studied. Mothers were recruited at the third trimester in two primary care centers and one private hospital in Jakarta, Indonesia. Mothers filled out questionnaires about exposure to non-organophosphate household pesticides at the 3rd trimester of pregnancy. Birth weight and length were measured at birth. Afterwards, the weight, height, and head circumference (HC) were measured at 7 days, 1, 2, 4, and 6 months of age. Linear mixed modeling and linear regression was performed to calculate growth rate of each infant. Multivariable linear regression adjusted for confounders was used to assess the association between household pesticides exposure and birth sizes and infant growth rate. Results Based on self-report questionnaires, 133 (46.8%) mothers were exposed to household pesticides during pregnancy. The mean HC at day 7 in the exposed group was − 7.1 mm (95%CI -13.1;-1.2) lower than in the non-exposed group. The difference was more prominent in the non-mosquito pesticide group (linear regression coefficient: − 22.1 mm, 95%CI -36.5;-7.6). No material associations were found between antenatal exposure to household pesticides with other growth measures, including weight gain, length gain, HC increment and weight-to-length gain rates. No modification of effects by breastfeeding was found. Conclusions Our findings suggest that antenatal exposure to household non-organophosphate pesticides is associated with smaller head circumference at birth.http://link.springer.com/article/10.1186/s12884-020-03162-w |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Frida Soesanti Nikmah S. Idris Kerstin Klipstein-Grobusch Aryono Hendarto Diederick E. Grobbee Cuno S. P. M. Uiterwaal |
spellingShingle |
Frida Soesanti Nikmah S. Idris Kerstin Klipstein-Grobusch Aryono Hendarto Diederick E. Grobbee Cuno S. P. M. Uiterwaal The effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study BMC Pregnancy and Childbirth |
author_facet |
Frida Soesanti Nikmah S. Idris Kerstin Klipstein-Grobusch Aryono Hendarto Diederick E. Grobbee Cuno S. P. M. Uiterwaal |
author_sort |
Frida Soesanti |
title |
The effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study |
title_short |
The effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study |
title_full |
The effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study |
title_fullStr |
The effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study |
title_full_unstemmed |
The effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study |
title_sort |
effect of non-organophosphate household pesticides exposure during pregnancy on infants birth sizes and growth rate: a cohort study |
publisher |
BMC |
series |
BMC Pregnancy and Childbirth |
issn |
1471-2393 |
publishDate |
2020-08-01 |
description |
Abstract Background To date, there is limited evidence on the effect of antenatal exposure to non-organophosphate household pesticides on infant health. Our hypothesis is that antenatal exposure to non-organophosphate household pesticides will be associated with birth sizes and infant growth rate. Methods In this prospective cohort study, 284 mother-infant pairs were studied. Mothers were recruited at the third trimester in two primary care centers and one private hospital in Jakarta, Indonesia. Mothers filled out questionnaires about exposure to non-organophosphate household pesticides at the 3rd trimester of pregnancy. Birth weight and length were measured at birth. Afterwards, the weight, height, and head circumference (HC) were measured at 7 days, 1, 2, 4, and 6 months of age. Linear mixed modeling and linear regression was performed to calculate growth rate of each infant. Multivariable linear regression adjusted for confounders was used to assess the association between household pesticides exposure and birth sizes and infant growth rate. Results Based on self-report questionnaires, 133 (46.8%) mothers were exposed to household pesticides during pregnancy. The mean HC at day 7 in the exposed group was − 7.1 mm (95%CI -13.1;-1.2) lower than in the non-exposed group. The difference was more prominent in the non-mosquito pesticide group (linear regression coefficient: − 22.1 mm, 95%CI -36.5;-7.6). No material associations were found between antenatal exposure to household pesticides with other growth measures, including weight gain, length gain, HC increment and weight-to-length gain rates. No modification of effects by breastfeeding was found. Conclusions Our findings suggest that antenatal exposure to household non-organophosphate pesticides is associated with smaller head circumference at birth. |
url |
http://link.springer.com/article/10.1186/s12884-020-03162-w |
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