Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272

Three new polyketides, ketidocillinones A−C (1−3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and...

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Main Authors:	Mudassir Shah, Chunxiao Sun, Zichao Sun, Guojian Zhang, Qian Che, Qianqun Gu, Tianjiao Zhu, Dehai Li
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Marine Drugs
Subjects:	antarctica sponge-derived fungus <i>penicillium</i> sp. polyketides antibacterial activity
Online Access:	https://www.mdpi.com/1660-3397/18/2/71

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spelling	doaj-8f408ee9e2eb49ff8cb00092c228ff142020-11-25T01:30:14ZengMDPI AGMarine Drugs1660-33972020-01-011827110.3390/md18020071md18020071Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272Mudassir Shah0Chunxiao Sun1Zichao Sun2Guojian Zhang3Qian Che4Qianqun Gu5Tianjiao Zhu6Dehai Li7Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaThree new polyketides, ketidocillinones A−C (<b>1</b>−<b>3</b>), were discovered from the extract of an Antarctica sponge-derived fungus <i>Penicillium</i> sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound <b>3</b> was established by using ECD calculation. Compounds <b>1</b>−<b>3</b> can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (<b>2</b> and <b>3</b>) exhibited potent antibacterial activity against <i>Pseudomonas aeurigenosa</i>, <i>Mycobacterium phlei</i>, and MRCNS (methicillin-resistant coagulase-negative <i>staphylococci</i>) with MIC values ranging from 1.56 to 25.00 µg/mL.https://www.mdpi.com/1660-3397/18/2/71antarctica sponge-derived fungus<i>penicillium</i> sp.polyketidesantibacterial activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mudassir Shah Chunxiao Sun Zichao Sun Guojian Zhang Qian Che Qianqun Gu Tianjiao Zhu Dehai Li
spellingShingle	Mudassir Shah Chunxiao Sun Zichao Sun Guojian Zhang Qian Che Qianqun Gu Tianjiao Zhu Dehai Li Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272 Marine Drugs antarctica sponge-derived fungus <i>penicillium</i> sp. polyketides antibacterial activity
author_facet	Mudassir Shah Chunxiao Sun Zichao Sun Guojian Zhang Qian Che Qianqun Gu Tianjiao Zhu Dehai Li
author_sort	Mudassir Shah
title	Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272
title_short	Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272
title_full	Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272
title_fullStr	Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272
title_full_unstemmed	Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272
title_sort	antibacterial polyketides from antarctica sponge-derived fungus <i>penicillium</i> sp. hdn151272
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2020-01-01
description	Three new polyketides, ketidocillinones A−C (<b>1</b>−<b>3</b>), were discovered from the extract of an Antarctica sponge-derived fungus <i>Penicillium</i> sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound <b>3</b> was established by using ECD calculation. Compounds <b>1</b>−<b>3</b> can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (<b>2</b> and <b>3</b>) exhibited potent antibacterial activity against <i>Pseudomonas aeurigenosa</i>, <i>Mycobacterium phlei</i>, and MRCNS (methicillin-resistant coagulase-negative <i>staphylococci</i>) with MIC values ranging from 1.56 to 25.00 µg/mL.
topic	antarctica sponge-derived fungus <i>penicillium</i> sp. polyketides antibacterial activity
url	https://www.mdpi.com/1660-3397/18/2/71
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Antibacterial Polyketides from Antarctica Sponge-Derived Fungus <i>Penicillium</i> sp. HDN151272

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