Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
Recently, the TAR DNA-binding protein-43 (TDP-43) has been identified as a major constituent of nuclear and/or cytoplasmic ubiquitin-positive inclusions in patient with amyotrophic lateral sclerosis or frontotemporal lobar degeneration. Pathological proteins are abnormally hyperphosphorylated and pa...
Main Authors: | Laetitia Miguel, Thierry Frébourg, Dominique Campion, Magalie Lecourtois |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2011-02-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996110003414 |
Similar Items
-
TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
by: Rachel Atkinson, et al.
Published: (2021-02-01) -
Molecular Neuropathology of TDP-43 Proteinopathies
by: Manuela Neumann
Published: (2009-01-01) -
Disease Animal Models of TDP-43 Proteinopathy and Their Pre-Clinical Applications
by: Kuen-Jer Tsai, et al.
Published: (2013-10-01) -
Mechanisms of TDP-43 Proteinopathy Onset and Propagation
by: Han-Jou Chen, et al.
Published: (2021-06-01) -
The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
by: Britt A. Berning, et al.
Published: (2019-04-01)