Role of the RIG-I-like receptors in antiviral response

• Main Authors: Agnieszka Jabłońska, Edyta Paradowska
• Format: Article
• Language: English
• Published: Index Copernicus International S.A. 2014-01-01
• Series: Postępy Higieny i Medycyny Doświadczalnej
• Subjects: innate immunity; cell receptors; virus; interferon
• Online Access: http://phmd.pl/gicid/01.3001.0003.1230

The innate nonspecific immunity is the first line of defense against viral infection. Toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are two main receptor families detecting viral nucleic acid. So far, three RLR family members were characterized: RIG-I, MDA5 and LGP2. RLR constitute a family of cytoplasmic helicases, which recognized intracellular single-stranded and double-stranded RNA that is introduced to cytosol during viral infection and replication. In this work we review the current knowledge about the mechanisms of viral recognition by RIG-I-like receptors and their signaling pathways for the activation of type I interferons and pro-inflammatory cytokines synthesis.