Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review

Abstract The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OL...

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Main Authors: Janaina Silva Martins HUMBERTO, Jefferson Veronezi PAVANIN, Maria José Alves da ROCHA, Ana Carolina Fragoso MOTTA
Format: Article
Language:English
Published: Sociedade Brasileira de Pesquisa Odontológica 2018-08-01
Series:Brazilian Oral Research
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100403&lng=en&tlng=en
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spelling doaj-8f67a1bff04b45298a157213f38540f72020-11-25T00:08:58ZengSociedade Brasileira de Pesquisa Odontológica Brazilian Oral Research1807-31072018-08-0132010.1590/1807-3107bor-2018.vol32.0082S1806-83242018000100403Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic reviewJanaina Silva Martins HUMBERTOJefferson Veronezi PAVANINMaria José Alves da ROCHAAna Carolina Fragoso MOTTAAbstract The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A total of 140 articles were retrieved, and 32 articles fulfilled the inclusion criteria (cytokines = 17; cortisol = 9; NO = 6). The most studied cytokines in the saliva of OLP patients were interleukins IL-4, IL-6, IL-8, IFN-ү, and TNF-α, which were higher in OLP patients than in healthy controls (HC). Salivary cortisol was found to be higher in OLP than in HC in most (55.5%) of the selected studies, and all studies related to NO found higher levels of this marker in OLP than in HC. Despite controversial results, our review suggests that OLP patients have an increased inflammatory response, as indicated by the proinflammatory profile of salivary cytokines. In addition, we conclude that salivary cytokine and NO measurements may have significant diagnostic and prognostic potential for monitoring disease activity and therapeutic responses in OLP.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100403&lng=en&tlng=enLichen Planus, OralSalivaBiomarkers
collection DOAJ
language English
format Article
sources DOAJ
author Janaina Silva Martins HUMBERTO
Jefferson Veronezi PAVANIN
Maria José Alves da ROCHA
Ana Carolina Fragoso MOTTA
spellingShingle Janaina Silva Martins HUMBERTO
Jefferson Veronezi PAVANIN
Maria José Alves da ROCHA
Ana Carolina Fragoso MOTTA
Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review
Brazilian Oral Research
Lichen Planus, Oral
Saliva
Biomarkers
author_facet Janaina Silva Martins HUMBERTO
Jefferson Veronezi PAVANIN
Maria José Alves da ROCHA
Ana Carolina Fragoso MOTTA
author_sort Janaina Silva Martins HUMBERTO
title Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review
title_short Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review
title_full Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review
title_fullStr Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review
title_full_unstemmed Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review
title_sort cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review
publisher Sociedade Brasileira de Pesquisa Odontológica
series Brazilian Oral Research
issn 1807-3107
publishDate 2018-08-01
description Abstract The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A total of 140 articles were retrieved, and 32 articles fulfilled the inclusion criteria (cytokines = 17; cortisol = 9; NO = 6). The most studied cytokines in the saliva of OLP patients were interleukins IL-4, IL-6, IL-8, IFN-ү, and TNF-α, which were higher in OLP patients than in healthy controls (HC). Salivary cortisol was found to be higher in OLP than in HC in most (55.5%) of the selected studies, and all studies related to NO found higher levels of this marker in OLP than in HC. Despite controversial results, our review suggests that OLP patients have an increased inflammatory response, as indicated by the proinflammatory profile of salivary cytokines. In addition, we conclude that salivary cytokine and NO measurements may have significant diagnostic and prognostic potential for monitoring disease activity and therapeutic responses in OLP.
topic Lichen Planus, Oral
Saliva
Biomarkers
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100403&lng=en&tlng=en
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