Potential therapeutic interventions via EP2/EP4 prostaglandin receptors
Prevention and treatment of pathological inflammatory processes requires application of various classes of immune suppressors, such as calcineurin inhibitors, steroids and non-steroid inhibitors of prostaglandin synthesis. However, each type of these immune suppressors causes less or more serious ad...
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Index Copernicus International S.A.
2012-05-01
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doaj-8f6b5a40538a40bdbc864439e888f8002020-11-24T22:12:48ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932012-05-0166855199287294Potential therapeutic interventions via EP2/EP4 prostaglandin receptorsMichał ZimeckiPrevention and treatment of pathological inflammatory processes requires application of various classes of immune suppressors, such as calcineurin inhibitors, steroids and non-steroid inhibitors of prostaglandin synthesis. However, each type of these immune suppressors causes less or more serious adverse side-effects. Exploration of the role played by prostanoids in the immune response and identification of functionally distinct prostaglandin E receptors (EP1-EP4) opened new perspectives in therapy of inflammation, autoimmunity and prevention of graft rejection. The EP4 receptor appeared to be an attractive target to affect manifestations of various pathological states by application of either agonists or antagonists of the receptor. This article presents a short overview of experimental approaches aimed at manipulation of signaling via EP2 and EP4 receptors that could have therapeutic utility.http://journals.indexcopernicus.com/fulltxt.php?ICID=998859EP4PGE2Inflammationimmune responsezapalenieodpowiedź immunologiczna |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michał Zimecki |
spellingShingle |
Michał Zimecki Potential therapeutic interventions via EP2/EP4 prostaglandin receptors Postępy Higieny i Medycyny Doświadczalnej EP4 PGE2 Inflammation immune response zapalenie odpowiedź immunologiczna |
author_facet |
Michał Zimecki |
author_sort |
Michał Zimecki |
title |
Potential therapeutic interventions via EP2/EP4 prostaglandin receptors |
title_short |
Potential therapeutic interventions via EP2/EP4 prostaglandin receptors |
title_full |
Potential therapeutic interventions via EP2/EP4 prostaglandin receptors |
title_fullStr |
Potential therapeutic interventions via EP2/EP4 prostaglandin receptors |
title_full_unstemmed |
Potential therapeutic interventions via EP2/EP4 prostaglandin receptors |
title_sort |
potential therapeutic interventions via ep2/ep4 prostaglandin receptors |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2012-05-01 |
description |
Prevention and treatment of pathological inflammatory processes requires application of various classes of immune suppressors, such as calcineurin inhibitors, steroids and non-steroid inhibitors of prostaglandin synthesis. However, each type of these immune suppressors causes less or more serious adverse side-effects. Exploration of the role played by prostanoids in the immune response and identification of functionally distinct prostaglandin E receptors (EP1-EP4) opened new perspectives in therapy of inflammation, autoimmunity and prevention of graft rejection. The EP4 receptor appeared to be an attractive target to affect manifestations of various pathological states by application of either agonists or antagonists of the receptor. This article presents a short overview of experimental approaches aimed at manipulation of signaling via EP2 and EP4 receptors that could have therapeutic utility. |
topic |
EP4 PGE2 Inflammation immune response zapalenie odpowiedź immunologiczna |
url |
http://journals.indexcopernicus.com/fulltxt.php?ICID=998859 |
work_keys_str_mv |
AT michałzimecki potentialtherapeuticinterventionsviaep2ep4prostaglandinreceptors |
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1725802309058822144 |