Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc

Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc

In myelinated fibres conduction and adhesion proteins aggregate at discrete foci, but it is unclear if this organization is present in other excitable cells. Using nanoscale visualization and in silico techniques, the authors show that adhesion/excitability nodes exist at the intercalated discs of a...

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Main Authors: Alejandra Leo-Macias, Esperanza Agullo-Pascual, Jose L. Sanchez-Alonso, Sarah Keegan, Xianming Lin, Tatiana Arcos, Feng-Xia-Liang, Yuri E. Korchev, Julia Gorelik, David Fenyö, Eli Rothenberg, Mario Delmar
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10342
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spelling doaj-8f789436985642779f392dca037fd8602021-05-11T11:12:12ZengNature Publishing GroupNature Communications2041-17232016-01-017111210.1038/ncomms10342Nanoscale visualization of functional adhesion/excitability nodes at the intercalated discAlejandra Leo-Macias0Esperanza Agullo-Pascual1Jose L. Sanchez-Alonso2Sarah Keegan3Xianming Lin4Tatiana Arcos5Feng-Xia-Liang6Yuri E. Korchev7Julia Gorelik8David Fenyö9Eli Rothenberg10Mario Delmar11The Leon H Charney Division of Cardiology, New York University School of Medicine (NYU-SoM)The Leon H Charney Division of Cardiology, New York University School of Medicine (NYU-SoM)Department of Cardiac Medicine, Imperial College, National Heart and Lung Institute, Imperial Center for Translational and Experimental Medicine, Hammersmith CampusCenter for Health Informatics and Bioinformatics, NYU-SoMThe Leon H Charney Division of Cardiology, New York University School of Medicine (NYU-SoM)The Leon H Charney Division of Cardiology, New York University School of Medicine (NYU-SoM)Microscopy Core, NYU-SoMDivision of Medicine, Imperial College, Hammersmith CampusDepartment of Cardiac Medicine, Imperial College, National Heart and Lung Institute, Imperial Center for Translational and Experimental Medicine, Hammersmith CampusCenter for Health Informatics and Bioinformatics, NYU-SoMDepartment of Biochemistry and Molecular Pharmacology, NYU-SoMThe Leon H Charney Division of Cardiology, New York University School of Medicine (NYU-SoM)In myelinated fibres conduction and adhesion proteins aggregate at discrete foci, but it is unclear if this organization is present in other excitable cells. Using nanoscale visualization and in silico techniques, the authors show that adhesion/excitability nodes exist at the intercalated discs of adult cardiac muscle.https://doi.org/10.1038/ncomms10342
collection DOAJ
language English
format Article
sources DOAJ
author Alejandra Leo-Macias
Esperanza Agullo-Pascual
Jose L. Sanchez-Alonso
Sarah Keegan
Xianming Lin
Tatiana Arcos
Feng-Xia-Liang
Yuri E. Korchev
Julia Gorelik
David Fenyö
Eli Rothenberg
Mario Delmar
spellingShingle Alejandra Leo-Macias
Esperanza Agullo-Pascual
Jose L. Sanchez-Alonso
Sarah Keegan
Xianming Lin
Tatiana Arcos
Feng-Xia-Liang
Yuri E. Korchev
Julia Gorelik
David Fenyö
Eli Rothenberg
Mario Delmar
Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc
Nature Communications
author_facet Alejandra Leo-Macias
Esperanza Agullo-Pascual
Jose L. Sanchez-Alonso
Sarah Keegan
Xianming Lin
Tatiana Arcos
Feng-Xia-Liang
Yuri E. Korchev
Julia Gorelik
David Fenyö
Eli Rothenberg
Mario Delmar
author_sort Alejandra Leo-Macias
title Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc
title_short Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc
title_full Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc
title_fullStr Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc
title_full_unstemmed Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc
title_sort nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-01-01
description In myelinated fibres conduction and adhesion proteins aggregate at discrete foci, but it is unclear if this organization is present in other excitable cells. Using nanoscale visualization and in silico techniques, the authors show that adhesion/excitability nodes exist at the intercalated discs of adult cardiac muscle.
url https://doi.org/10.1038/ncomms10342
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