Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future?
Cystic echinococcosis (CE) is an important helminthic zoonotic disease caused by the Echinococcus granulosus complex. In humans, CE is a chronic disease driven by the growth of echinococcal cysts in different organs. Prognosis of this disease depends on multiple factors, including location, number,...
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doaj-8f7ff3cbe1334b43a3b00ed4cd83bf842020-11-24T21:06:31ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/428205428205Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future?Raúl Manzano-Román0Carlos Sánchez-Ovejero1Ana Hernández-González2Adriano Casulli3Mar Siles-Lucas4Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC), Cordel de Merinas 40-52, 37008 Salamanca, SpainInstituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC), Cordel de Merinas 40-52, 37008 Salamanca, SpainInstituto de Salud Carlos III, Centro Nacional de Microbiología, Majadahonda, 28220 Madrid, SpainIstituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyInstituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC), Cordel de Merinas 40-52, 37008 Salamanca, SpainCystic echinococcosis (CE) is an important helminthic zoonotic disease caused by the Echinococcus granulosus complex. In humans, CE is a chronic disease driven by the growth of echinococcal cysts in different organs. Prognosis of this disease depends on multiple factors, including location, number, size, and stage of the cysts, making CE a disease of complex management. CE is usually asymptomatic for years and attracts limited attention from funding organizations and health authorities. For this reason, only experts’ recommendations are available but no evidence-based conclusions have been drawn for CE clinical management. One of those pitfalls refers to the lack of evidence to support the use of serological tools for the diagnosis and follow-up of CE patients. In this respect, crude antigens are used to detect specific antibodies in patients, giving rise to false positive results. The advent of molecular techniques allowing the production of recombinant proteins has provided a number of candidate antigens that could overcome the problems associated with the use of crude parasite extracts in the serological assays. In this review, we present the last advances in this field, proposing the use of serology to support cyst stage-specific diagnosis and follow-up.http://dx.doi.org/10.1155/2015/428205 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raúl Manzano-Román Carlos Sánchez-Ovejero Ana Hernández-González Adriano Casulli Mar Siles-Lucas |
spellingShingle |
Raúl Manzano-Román Carlos Sánchez-Ovejero Ana Hernández-González Adriano Casulli Mar Siles-Lucas Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? BioMed Research International |
author_facet |
Raúl Manzano-Román Carlos Sánchez-Ovejero Ana Hernández-González Adriano Casulli Mar Siles-Lucas |
author_sort |
Raúl Manzano-Román |
title |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
title_short |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
title_full |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
title_fullStr |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
title_full_unstemmed |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
title_sort |
serological diagnosis and follow-up of human cystic echinococcosis: a new hope for the future? |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Cystic echinococcosis (CE) is an important helminthic zoonotic disease caused by the Echinococcus granulosus complex. In humans, CE is a chronic disease driven by the growth of echinococcal cysts in different organs. Prognosis of this disease depends on multiple factors, including location, number, size, and stage of the cysts, making CE a disease of complex management. CE is usually asymptomatic for years and attracts limited attention from funding organizations and health authorities. For this reason, only experts’ recommendations are available but no evidence-based conclusions have been drawn for CE clinical management. One of those pitfalls refers to the lack of evidence to support the use of serological tools for the diagnosis and follow-up of CE patients. In this respect, crude antigens are used to detect specific antibodies in patients, giving rise to false positive results. The advent of molecular techniques allowing the production of recombinant proteins has provided a number of candidate antigens that could overcome the problems associated with the use of crude parasite extracts in the serological assays. In this review, we present the last advances in this field, proposing the use of serology to support cyst stage-specific diagnosis and follow-up. |
url |
http://dx.doi.org/10.1155/2015/428205 |
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