A severe case of levothyroxine intoxication successfully treated in intensive care unit

• Main Authors: Yusuf Savran, Tugce Mengi, Merve Keskinkilic
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Journal of Acute Disease
• Subjects: Levothyroxine; Intoxication; Critical care; Suicide
• Online Access: http://www.jadweb.org/article.asp?issn=2221-6189;year=2018;volume=7;issue=4;spage=175;epage=177;aulast=Savran

Levothyroxine intoxication is a rare clinical entity which is usually asymptomatic. However, severe symptoms such as respiratory failure, malignant hyperthermia, seizures, arrhythmia, and coma have been reported. In this case report, a patient who ingested high dose (15 mg) levothyroxine for suicide and admitted to intensive care unit was presented. There was a decrease in Glasgow coma score in the follow-up. The patient was intubated due to acute respiratory failure. Gastric lavage, activated charcoal, methylprednisolone, cholestyramine and therapeuthic plasma exchange were administered. Despite ingestion of high dose of levothyroxine, thyrotoxicosis symptoms resolved with appropriate treatment and the patient was discharged from the intensive care unit.