Doxorubicin induces inflammatory modulation and metabolic dysregulation in diabetic skeletal muscle

Doxorubicin induces inflammatory modulation and metabolic dysregulation in diabetic skeletal muscle

Anti-cancer agent doxorubicin (DOX) has been demonstrated to worsen insulin signaling, engender muscle atrophy, trigger pro-inflammation, and induce a shift to anaerobic glycolytic metabolism in skeletal muscle. The myotoxicity of DOX in diabetic skeletal muscle remains largely unclear. This study e...

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Bibliographic Details
Main Authors: Rashmi Supriya, Bjorn Tam, Xiao Pei, Christopher Lai, Lawrence Wing Chi Chan, Benjamin Yung, Parco M Siu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Physiology
Subjects:
anti-inflammation
type 2 diabetes mellitus
cancer chemotherapy
myotoxicity
Anaerobic glycolysis
Pro-inflammation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00323/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00323/full

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