Doxorubicin induces inflammatory modulation and metabolic dysregulation in diabetic skeletal muscle
Anti-cancer agent doxorubicin (DOX) has been demonstrated to worsen insulin signaling, engender muscle atrophy, trigger pro-inflammation, and induce a shift to anaerobic glycolytic metabolism in skeletal muscle. The myotoxicity of DOX in diabetic skeletal muscle remains largely unclear. This study e...
Main Authors: | Rashmi Supriya, Bjorn Tam, Xiao Pei, Christopher Lai, Lawrence Wing Chi Chan, Benjamin Yung, Parco M Siu |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2016-07-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00323/full |
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