New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring
In recent years, the number of cases with severe Plasmodium vivax malaria has shown an increasing trend. It is, therefore, important to identify routine laboratory markers that best characterize the acute disease phase and can serve as a tool for clinical follow-up of patients. In a cohort study, we...
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doaj-8fa88c57f3264bf7afd17603be0e6da42020-11-25T02:53:12ZengElsevierBrazilian Journal of Infectious Diseases1413-86702020-03-01242120129New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoringEduardo Rodrigues Alves-Junior0Luciano Teixeira Gomes1Thaís Caroline Dallabona Dombroski2Andréia Ferreira Nery3Samuel Vandresen-Filho4Luciano Nakazato5Cor Jesus Fernandes Fontes6Fabrício Rios-Santos7Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, MT, Brazil; Centro Universitário de Várzea Grande, Departamento de Ciencias da Saúde, Varzea Grande, MT, Brazil; Corresponding author.Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, MT, Brazil; Hospital Universitário Julio Muller, Cuiabá, MT, BrazilCentro Universitário de Várzea Grande, Departamento de Ciencias da Saúde, Varzea Grande, MT, BrazilUniversidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, MT, Brazil; Hospital Universitário Julio Muller, Cuiabá, MT, Brazil; Faculdade de Ciências Biomédicas, Cacoal, RO, BrazilUniversidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, MT, BrazilUniversidade Federal de Mato Grosso, Hospital Veterinário e Laboratório de Microbiologia e Biologia Molecular Veterinária, Cuiabá, MT, BrazilUniversidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, MT, Brazil; Hospital Universitário Julio Muller, Cuiabá, MT, Brazil; Faculdade de Ciências Biomédicas, Cacoal, RO, BrazilUniversidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, MT, BrazilIn recent years, the number of cases with severe Plasmodium vivax malaria has shown an increasing trend. It is, therefore, important to identify routine laboratory markers that best characterize the acute disease phase and can serve as a tool for clinical follow-up of patients. In a cohort study, we followed 87 patients with acute P. vivax monoinfection acquired in an endemic region of the Brazilian Amazon. Forty-two different biochemical and hematological parameters frequently tested in clinical routine were evaluated at the acute phase and the convalescent phase. A total of 42 laboratory tests were performed: biochemical parameters measured were serum lipids levels, aminotransferases, bilirubin, amylase, glucose, urea, creatinine, albumin, globulin, uric acid, C-reactive protein, and alpha-1-acid glycoprotein. Hematological parameters included total and differential white blood cell and platelet counts, hemoglobin concentration, mean platelet volume, platelet width distribution, and plateletcrit. Our results show that several biochemical and hematological parameters were associated with acute phase P. vivax malaria and these parameters reverted to normal values in the convalescent phase. The use of these parameters during diagnosis and follow-up of the infection is a useful clinical tool to evaluate the clinical course and therapeutic response of patients with uncomplicated vivax malaria.http://www.sciencedirect.com/science/article/pii/S1413867020300271Plasmodium vivaxLaboratory biomarkersAcute phasePrognosisClinical status |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eduardo Rodrigues Alves-Junior Luciano Teixeira Gomes Thaís Caroline Dallabona Dombroski Andréia Ferreira Nery Samuel Vandresen-Filho Luciano Nakazato Cor Jesus Fernandes Fontes Fabrício Rios-Santos |
spellingShingle |
Eduardo Rodrigues Alves-Junior Luciano Teixeira Gomes Thaís Caroline Dallabona Dombroski Andréia Ferreira Nery Samuel Vandresen-Filho Luciano Nakazato Cor Jesus Fernandes Fontes Fabrício Rios-Santos New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring Brazilian Journal of Infectious Diseases Plasmodium vivax Laboratory biomarkers Acute phase Prognosis Clinical status |
author_facet |
Eduardo Rodrigues Alves-Junior Luciano Teixeira Gomes Thaís Caroline Dallabona Dombroski Andréia Ferreira Nery Samuel Vandresen-Filho Luciano Nakazato Cor Jesus Fernandes Fontes Fabrício Rios-Santos |
author_sort |
Eduardo Rodrigues Alves-Junior |
title |
New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring |
title_short |
New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring |
title_full |
New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring |
title_fullStr |
New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring |
title_full_unstemmed |
New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring |
title_sort |
new laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2020-03-01 |
description |
In recent years, the number of cases with severe Plasmodium vivax malaria has shown an increasing trend. It is, therefore, important to identify routine laboratory markers that best characterize the acute disease phase and can serve as a tool for clinical follow-up of patients. In a cohort study, we followed 87 patients with acute P. vivax monoinfection acquired in an endemic region of the Brazilian Amazon. Forty-two different biochemical and hematological parameters frequently tested in clinical routine were evaluated at the acute phase and the convalescent phase. A total of 42 laboratory tests were performed: biochemical parameters measured were serum lipids levels, aminotransferases, bilirubin, amylase, glucose, urea, creatinine, albumin, globulin, uric acid, C-reactive protein, and alpha-1-acid glycoprotein. Hematological parameters included total and differential white blood cell and platelet counts, hemoglobin concentration, mean platelet volume, platelet width distribution, and plateletcrit. Our results show that several biochemical and hematological parameters were associated with acute phase P. vivax malaria and these parameters reverted to normal values in the convalescent phase. The use of these parameters during diagnosis and follow-up of the infection is a useful clinical tool to evaluate the clinical course and therapeutic response of patients with uncomplicated vivax malaria. |
topic |
Plasmodium vivax Laboratory biomarkers Acute phase Prognosis Clinical status |
url |
http://www.sciencedirect.com/science/article/pii/S1413867020300271 |
work_keys_str_mv |
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