Using Blood Eosinophil Count as a Biomarker to Guide Corticosteroid Treatment for Chronic Obstructive Pulmonary Disease
Treating patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease (COPD) usually involves administering systemic corticosteroids. The many unwanted side effects associated with this treatment have led to increased interest in minimising the accumulated corticosteroid d...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
|
Series: | Diagnostics |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4418/11/2/236 |
id |
doaj-8fadf43300254e10a61f18341924c4e9 |
---|---|
record_format |
Article |
spelling |
doaj-8fadf43300254e10a61f18341924c4e92021-02-04T00:06:25ZengMDPI AGDiagnostics2075-44182021-02-011123623610.3390/diagnostics11020236Using Blood Eosinophil Count as a Biomarker to Guide Corticosteroid Treatment for Chronic Obstructive Pulmonary DiseasePradeesh Sivapalan0András Bikov1Jens-Ulrik Jensen2Respiratory Medicine Section, Department of Internal Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, DenmarkWythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKRespiratory Medicine Section, Department of Internal Medicine, Herlev-Gentofte Hospital, 2900 Hellerup, DenmarkTreating patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease (COPD) usually involves administering systemic corticosteroids. The many unwanted side effects associated with this treatment have led to increased interest in minimising the accumulated corticosteroid dose necessary to treat exacerbations. Studies have shown that short-term treatment with corticosteroids is preferred, and recent trials have shown that biomarkers can be used to further reduce exposure to corticosteroids. Interestingly, high eosinophil counts in patients with acute exacerbations of COPD are indicative of an eosinophilic phenotype with a distinct response to treatment with corticosteroids. In addition, post-hoc analysis of randomised control trials have shown that higher blood eosinophil counts at the start of the study predict a greater response to inhaled corticosteroids in stable COPD. In this review, we examine the studies on this topic, describe how blood eosinophil cell count may be used as a biomarker to guide treatment with corticosteroids, and identify some relevant challenges.https://www.mdpi.com/2075-4418/11/2/236chronic obstructive pulmonary diseaseblood eosinophil countsystemic corticosteroidsbiomarkersinhaled corticosteroids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pradeesh Sivapalan András Bikov Jens-Ulrik Jensen |
spellingShingle |
Pradeesh Sivapalan András Bikov Jens-Ulrik Jensen Using Blood Eosinophil Count as a Biomarker to Guide Corticosteroid Treatment for Chronic Obstructive Pulmonary Disease Diagnostics chronic obstructive pulmonary disease blood eosinophil count systemic corticosteroids biomarkers inhaled corticosteroids |
author_facet |
Pradeesh Sivapalan András Bikov Jens-Ulrik Jensen |
author_sort |
Pradeesh Sivapalan |
title |
Using Blood Eosinophil Count as a Biomarker to Guide Corticosteroid Treatment for Chronic Obstructive Pulmonary Disease |
title_short |
Using Blood Eosinophil Count as a Biomarker to Guide Corticosteroid Treatment for Chronic Obstructive Pulmonary Disease |
title_full |
Using Blood Eosinophil Count as a Biomarker to Guide Corticosteroid Treatment for Chronic Obstructive Pulmonary Disease |
title_fullStr |
Using Blood Eosinophil Count as a Biomarker to Guide Corticosteroid Treatment for Chronic Obstructive Pulmonary Disease |
title_full_unstemmed |
Using Blood Eosinophil Count as a Biomarker to Guide Corticosteroid Treatment for Chronic Obstructive Pulmonary Disease |
title_sort |
using blood eosinophil count as a biomarker to guide corticosteroid treatment for chronic obstructive pulmonary disease |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2021-02-01 |
description |
Treating patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease (COPD) usually involves administering systemic corticosteroids. The many unwanted side effects associated with this treatment have led to increased interest in minimising the accumulated corticosteroid dose necessary to treat exacerbations. Studies have shown that short-term treatment with corticosteroids is preferred, and recent trials have shown that biomarkers can be used to further reduce exposure to corticosteroids. Interestingly, high eosinophil counts in patients with acute exacerbations of COPD are indicative of an eosinophilic phenotype with a distinct response to treatment with corticosteroids. In addition, post-hoc analysis of randomised control trials have shown that higher blood eosinophil counts at the start of the study predict a greater response to inhaled corticosteroids in stable COPD. In this review, we examine the studies on this topic, describe how blood eosinophil cell count may be used as a biomarker to guide treatment with corticosteroids, and identify some relevant challenges. |
topic |
chronic obstructive pulmonary disease blood eosinophil count systemic corticosteroids biomarkers inhaled corticosteroids |
url |
https://www.mdpi.com/2075-4418/11/2/236 |
work_keys_str_mv |
AT pradeeshsivapalan usingbloodeosinophilcountasabiomarkertoguidecorticosteroidtreatmentforchronicobstructivepulmonarydisease AT andrasbikov usingbloodeosinophilcountasabiomarkertoguidecorticosteroidtreatmentforchronicobstructivepulmonarydisease AT jensulrikjensen usingbloodeosinophilcountasabiomarkertoguidecorticosteroidtreatmentforchronicobstructivepulmonarydisease |
_version_ |
1724285731418931200 |