Regulation of the Development and Function of B Cells by ZBTB Transcription Factors
The large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB proteins have emerged as critical factors that regulate the lineage commitment, differentiation, and function of lymphoid cells as well as many other developmental events. For instance, dysfunctions of ZBTB20 or...
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doaj-8fb3543fcce346da87ac4f2d27d2a6112020-11-24T20:51:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-03-01910.3389/fimmu.2018.00580352009Regulation of the Development and Function of B Cells by ZBTB Transcription FactorsCan Zhu0Ge Chen1Ying Zhao2Xiao-Ming Gao3Jun Wang4Institutes of Biology and Medical Sciences, Soochow University, Suzhou, ChinaInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, ChinaDepartment of Pathophysiology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, ChinaInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, ChinaInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, ChinaThe large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB proteins have emerged as critical factors that regulate the lineage commitment, differentiation, and function of lymphoid cells as well as many other developmental events. For instance, dysfunctions of ZBTB20 or ZBTB24 have been linked to multisystem failures in humans. Within the B-cell lineage, BCL6, ZBTB7A, ZBTB17, and ZBTB1 regulate the development/differentiation of B cells in both bone marrow and peripheral lymphoid organs, while ZBTB20 and ZBTB32 seem to mainly impact the maintenance of terminal plasma cells. Given the importance of B cells in the prevention and treatment of infectious or autoimmune disorders, we herein summarize the roles of seven ZBTB family members (BCL6, ZBTB7A, ZBTB17, ZBTB20, ZBTB32, ZBTB1, and ZBTB24) in the development, differentiation, and function of B cells as well as the underlying molecular mechanisms.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00580/fullB cellsBCL6ZBTB7AZBTB17ZBTB20ZBTB32 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Can Zhu Ge Chen Ying Zhao Xiao-Ming Gao Jun Wang |
spellingShingle |
Can Zhu Ge Chen Ying Zhao Xiao-Ming Gao Jun Wang Regulation of the Development and Function of B Cells by ZBTB Transcription Factors Frontiers in Immunology B cells BCL6 ZBTB7A ZBTB17 ZBTB20 ZBTB32 |
author_facet |
Can Zhu Ge Chen Ying Zhao Xiao-Ming Gao Jun Wang |
author_sort |
Can Zhu |
title |
Regulation of the Development and Function of B Cells by ZBTB Transcription Factors |
title_short |
Regulation of the Development and Function of B Cells by ZBTB Transcription Factors |
title_full |
Regulation of the Development and Function of B Cells by ZBTB Transcription Factors |
title_fullStr |
Regulation of the Development and Function of B Cells by ZBTB Transcription Factors |
title_full_unstemmed |
Regulation of the Development and Function of B Cells by ZBTB Transcription Factors |
title_sort |
regulation of the development and function of b cells by zbtb transcription factors |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-03-01 |
description |
The large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB proteins have emerged as critical factors that regulate the lineage commitment, differentiation, and function of lymphoid cells as well as many other developmental events. For instance, dysfunctions of ZBTB20 or ZBTB24 have been linked to multisystem failures in humans. Within the B-cell lineage, BCL6, ZBTB7A, ZBTB17, and ZBTB1 regulate the development/differentiation of B cells in both bone marrow and peripheral lymphoid organs, while ZBTB20 and ZBTB32 seem to mainly impact the maintenance of terminal plasma cells. Given the importance of B cells in the prevention and treatment of infectious or autoimmune disorders, we herein summarize the roles of seven ZBTB family members (BCL6, ZBTB7A, ZBTB17, ZBTB20, ZBTB32, ZBTB1, and ZBTB24) in the development, differentiation, and function of B cells as well as the underlying molecular mechanisms. |
topic |
B cells BCL6 ZBTB7A ZBTB17 ZBTB20 ZBTB32 |
url |
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00580/full |
work_keys_str_mv |
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1716802656661405696 |