Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells
Cardiosphere-derived cells (CDCs) are progenitor cells derived from heart tissue and have shown promising results in preclinical models. APOSEC, the secretome of irradiated peripheral blood mononuclear cells, has decreased infarct size in acute and chronic experimental myocardial infarction (MI). We...
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-09-01
|
Series: | Molecular Therapy: Methods & Clinical Development |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2329050120301327 |
id |
doaj-8fb9d32870534bee944827176257791e |
---|---|
record_format |
Article |
spelling |
doaj-8fb9d32870534bee944827176257791e2020-11-25T02:54:23ZengElsevierMolecular Therapy: Methods & Clinical Development2329-05012020-09-0118354366Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived CellsJohannes Winkler0Dominika Lukovic1Julia Mester-Tonczar2Katrin Zlabinger3Alfred Gugerell4Noemi Pavo5András Jakab6Zsuzsanna Szankai7Denise Traxler8Claudia Müller9Andreas Spannbauer10Martin Riesenhuber11Ena Hašimbegović12James Dawkins13Matthias Zimmermann14Hendrik J. Ankersmit15Eduardo Marbán16Mariann Gyöngyösi17Department of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Center for MR-Research, University Children’s Hospital Zurich, Steinwiesstrasse 7e, 80cb Zurich, SwitzerlandDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaDepartment of Cardiology, Medical University of Vienna, Vienna, AustriaSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USADivision of Thoracic Surgery, Medical University of Vienna, Vienna, AustriaDivision of Thoracic Surgery, Medical University of Vienna, Vienna, AustriaSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USADepartment of Cardiology, Medical University of Vienna, Vienna, Austria; Corresponding author: Mariann Gyöngyösi, Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.Cardiosphere-derived cells (CDCs) are progenitor cells derived from heart tissue and have shown promising results in preclinical models. APOSEC, the secretome of irradiated peripheral blood mononuclear cells, has decreased infarct size in acute and chronic experimental myocardial infarction (MI). We enhanced the effect of CDCs with APOSEC preconditioning (apoCDC) and investigated the reparative effect in a translational pig model of reperfused MI. Supernatants of CDCs, assessed by proteomic analysis, revealed reduced production of extracellular matrix proteins after in vitro APOSEC preconditioning. In a porcine model of catheter-based reperfused anterior acute MI (AMI), CDCs with (apoCDC, n = 8) or without APOSEC preconditioning (CDC, n = 6) were infused intracoronary, 15 min after the start of reperfusion. Untreated AMI animals (n = 7) and sham procedures (n = 5) functioned as controls. 2-deoxy-2-(18 F)-fluoro-D-glucose-positron emission tomography-magnetic resonance imaging ([18F]FDG-PET-MRI), with late enhancement after 1 month, showed reduced scar volume and lower transmurality of the infarcted area in CDC and apoCDC compared to AMI controls. Segmental quantitative PET images displayed indicated more residual viability in apoCDC. The left-ventricle (LV) ejection fraction was improved nonsignificantly to 45.8% ± 8.6% for apoCDC and 43.5% ± 7.1% for CDCs compared to 38.5% ± 4.4% for untreated AMI. Quantitative hybrid [18F]FDG-PET-MRI demonstrated improved metabolic and functional recovery after CDC administration, whereas apoCDCs induced preservation of viability of the infarcted area.http://www.sciencedirect.com/science/article/pii/S2329050120301327heart failuremagnetic resonance imagingmyocardial regenerationnuclear cardiologyPETstem cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Johannes Winkler Dominika Lukovic Julia Mester-Tonczar Katrin Zlabinger Alfred Gugerell Noemi Pavo András Jakab Zsuzsanna Szankai Denise Traxler Claudia Müller Andreas Spannbauer Martin Riesenhuber Ena Hašimbegović James Dawkins Matthias Zimmermann Hendrik J. Ankersmit Eduardo Marbán Mariann Gyöngyösi |
spellingShingle |
Johannes Winkler Dominika Lukovic Julia Mester-Tonczar Katrin Zlabinger Alfred Gugerell Noemi Pavo András Jakab Zsuzsanna Szankai Denise Traxler Claudia Müller Andreas Spannbauer Martin Riesenhuber Ena Hašimbegović James Dawkins Matthias Zimmermann Hendrik J. Ankersmit Eduardo Marbán Mariann Gyöngyösi Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells Molecular Therapy: Methods & Clinical Development heart failure magnetic resonance imaging myocardial regeneration nuclear cardiology PET stem cells |
author_facet |
Johannes Winkler Dominika Lukovic Julia Mester-Tonczar Katrin Zlabinger Alfred Gugerell Noemi Pavo András Jakab Zsuzsanna Szankai Denise Traxler Claudia Müller Andreas Spannbauer Martin Riesenhuber Ena Hašimbegović James Dawkins Matthias Zimmermann Hendrik J. Ankersmit Eduardo Marbán Mariann Gyöngyösi |
author_sort |
Johannes Winkler |
title |
Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells |
title_short |
Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells |
title_full |
Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells |
title_fullStr |
Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells |
title_full_unstemmed |
Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells |
title_sort |
quantitative hybrid cardiac [18f]fdg-pet-mri images for assessment of cardiac repair by preconditioned cardiosphere-derived cells |
publisher |
Elsevier |
series |
Molecular Therapy: Methods & Clinical Development |
issn |
2329-0501 |
publishDate |
2020-09-01 |
description |
Cardiosphere-derived cells (CDCs) are progenitor cells derived from heart tissue and have shown promising results in preclinical models. APOSEC, the secretome of irradiated peripheral blood mononuclear cells, has decreased infarct size in acute and chronic experimental myocardial infarction (MI). We enhanced the effect of CDCs with APOSEC preconditioning (apoCDC) and investigated the reparative effect in a translational pig model of reperfused MI. Supernatants of CDCs, assessed by proteomic analysis, revealed reduced production of extracellular matrix proteins after in vitro APOSEC preconditioning. In a porcine model of catheter-based reperfused anterior acute MI (AMI), CDCs with (apoCDC, n = 8) or without APOSEC preconditioning (CDC, n = 6) were infused intracoronary, 15 min after the start of reperfusion. Untreated AMI animals (n = 7) and sham procedures (n = 5) functioned as controls. 2-deoxy-2-(18 F)-fluoro-D-glucose-positron emission tomography-magnetic resonance imaging ([18F]FDG-PET-MRI), with late enhancement after 1 month, showed reduced scar volume and lower transmurality of the infarcted area in CDC and apoCDC compared to AMI controls. Segmental quantitative PET images displayed indicated more residual viability in apoCDC. The left-ventricle (LV) ejection fraction was improved nonsignificantly to 45.8% ± 8.6% for apoCDC and 43.5% ± 7.1% for CDCs compared to 38.5% ± 4.4% for untreated AMI. Quantitative hybrid [18F]FDG-PET-MRI demonstrated improved metabolic and functional recovery after CDC administration, whereas apoCDCs induced preservation of viability of the infarcted area. |
topic |
heart failure magnetic resonance imaging myocardial regeneration nuclear cardiology PET stem cells |
url |
http://www.sciencedirect.com/science/article/pii/S2329050120301327 |
work_keys_str_mv |
AT johanneswinkler quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT dominikalukovic quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT juliamestertonczar quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT katrinzlabinger quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT alfredgugerell quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT noemipavo quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT andrasjakab quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT zsuzsannaszankai quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT denisetraxler quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT claudiamuller quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT andreasspannbauer quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT martinriesenhuber quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT enahasimbegovic quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT jamesdawkins quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT matthiaszimmermann quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT hendrikjankersmit quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT eduardomarban quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells AT marianngyongyosi quantitativehybridcardiac18ffdgpetmriimagesforassessmentofcardiacrepairbypreconditionedcardiospherederivedcells |
_version_ |
1724721536907083776 |