A mathematical model for the effects of amyloid beta on intracellular calcium.
The accumulation of Alzheimer's disease (AD) associated Amyloid beta (Aβ) oligomers can trigger aberrant intracellular calcium (Ca2+) levels by disrupting the intrinsic Ca2+ regulatory mechanism within cells. These disruptions can cause changes in homeostasis levels that can have detrimental ef...
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doaj-8fc149343163449caf24a23b89d2f2872020-11-25T01:00:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01138e020250310.1371/journal.pone.0202503A mathematical model for the effects of amyloid beta on intracellular calcium.Joe LatulippeDerek LotitoDonovan MurbyThe accumulation of Alzheimer's disease (AD) associated Amyloid beta (Aβ) oligomers can trigger aberrant intracellular calcium (Ca2+) levels by disrupting the intrinsic Ca2+ regulatory mechanism within cells. These disruptions can cause changes in homeostasis levels that can have detrimental effects on cell function and survival. Although studies have shown that Aβ can interfere with various Ca2+ fluxes, the complexity of these interactions remains elusive. We have constructed a mathematical model that simulates Ca2+ patterns under the influence of Aβ. Our simulations shows that Aβ can increase regions of mixed-mode oscillations leading to aberrant signals under various conditions. We investigate how Aβ affects individual flux contributions through inositol triphosphate (IP3) receptors, ryanodine receptors, and membrane pores. We demonstrate that controlling for the ryanodine receptor's maximal kinetic reaction rate may provide a biophysical way of managing aberrant Ca2+ signals. The influence of a dynamic model for IP3 production is also investigated under various conditions as well as the impact of changes in membrane potential. Our model is one of the first to investigate the effects of Aβ on a variety of cellular mechanisms providing a base modeling scheme from which further studies can draw on to better understand Ca2+ regulation in an AD environment.http://europepmc.org/articles/PMC6105003?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joe Latulippe Derek Lotito Donovan Murby |
spellingShingle |
Joe Latulippe Derek Lotito Donovan Murby A mathematical model for the effects of amyloid beta on intracellular calcium. PLoS ONE |
author_facet |
Joe Latulippe Derek Lotito Donovan Murby |
author_sort |
Joe Latulippe |
title |
A mathematical model for the effects of amyloid beta on intracellular calcium. |
title_short |
A mathematical model for the effects of amyloid beta on intracellular calcium. |
title_full |
A mathematical model for the effects of amyloid beta on intracellular calcium. |
title_fullStr |
A mathematical model for the effects of amyloid beta on intracellular calcium. |
title_full_unstemmed |
A mathematical model for the effects of amyloid beta on intracellular calcium. |
title_sort |
mathematical model for the effects of amyloid beta on intracellular calcium. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
The accumulation of Alzheimer's disease (AD) associated Amyloid beta (Aβ) oligomers can trigger aberrant intracellular calcium (Ca2+) levels by disrupting the intrinsic Ca2+ regulatory mechanism within cells. These disruptions can cause changes in homeostasis levels that can have detrimental effects on cell function and survival. Although studies have shown that Aβ can interfere with various Ca2+ fluxes, the complexity of these interactions remains elusive. We have constructed a mathematical model that simulates Ca2+ patterns under the influence of Aβ. Our simulations shows that Aβ can increase regions of mixed-mode oscillations leading to aberrant signals under various conditions. We investigate how Aβ affects individual flux contributions through inositol triphosphate (IP3) receptors, ryanodine receptors, and membrane pores. We demonstrate that controlling for the ryanodine receptor's maximal kinetic reaction rate may provide a biophysical way of managing aberrant Ca2+ signals. The influence of a dynamic model for IP3 production is also investigated under various conditions as well as the impact of changes in membrane potential. Our model is one of the first to investigate the effects of Aβ on a variety of cellular mechanisms providing a base modeling scheme from which further studies can draw on to better understand Ca2+ regulation in an AD environment. |
url |
http://europepmc.org/articles/PMC6105003?pdf=render |
work_keys_str_mv |
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