Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance
FosB, a Mg2+ dependent thioltransferase, confers antibiotic resistance to fosfomycin through enzymatic drug inactivation. Among all antibiotic resistant proteins in the Antibiotic Resistance Genes Database and the Comprehensive Antibiotic Resistance Database, FosB is within 5% of the most number of...
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doaj-8fcfe6bf919f42faa8559801b4a08a7a2020-11-24T21:38:16ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-02-011010.3389/fmicb.2019.00200426911Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin ResistanceZiwei Song0Ziwei Song1Ziwei Song2Xue Wang3Xue Wang4Xingchen Zhou5Xingchen Zhou6Su Jiang7Yuanyuan Li8Owais Ahmad9Owais Ahmad10Owais Ahmad11Lianwen Qi12Lianwen Qi13Ping Li14Ping Li15Jing Li16Jing Li17School of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, ChinaSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaKey Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, ChinaSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaKey Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, ChinaSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, ChinaSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaClinical Metabolomics Center, China Pharmaceutical University, Nanjing, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, ChinaSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, ChinaKey Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, ChinaFosB, a Mg2+ dependent thioltransferase, confers antibiotic resistance to fosfomycin through enzymatic drug inactivation. Among all antibiotic resistant proteins in the Antibiotic Resistance Genes Database and the Comprehensive Antibiotic Resistance Database, FosB is within 5% of the most number of ARPs identified in Human Microbiome Project reference database but mainly distributed in limited genera, i.e., 122 of total 133 FosB homologues are found from Bacillus and Staphylococcus. Furthermore, these FosB sequences could be divided into three clusters based on their phylogenetic relationship, i.e., two groups of FosB were mainly from Bacillus, and another was mainly from Staphylococcus. Finally, we confirmed that FosB from the group of Staphylococcus presented the highest resistance ability to fosfomycin by in silico and in vitro comparisons. In summary, this study elaborates the specific taxonomic characteristics and resistant abilities of FosB in human microbiota, which might help in developing more promising fosfomycin-like antibiotics.https://www.frontiersin.org/article/10.3389/fmicb.2019.00200/fullFosBfosfomycinantibiotic resistance proteinsgut microbiotaStaphylococcus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ziwei Song Ziwei Song Ziwei Song Xue Wang Xue Wang Xingchen Zhou Xingchen Zhou Su Jiang Yuanyuan Li Owais Ahmad Owais Ahmad Owais Ahmad Lianwen Qi Lianwen Qi Ping Li Ping Li Jing Li Jing Li |
spellingShingle |
Ziwei Song Ziwei Song Ziwei Song Xue Wang Xue Wang Xingchen Zhou Xingchen Zhou Su Jiang Yuanyuan Li Owais Ahmad Owais Ahmad Owais Ahmad Lianwen Qi Lianwen Qi Ping Li Ping Li Jing Li Jing Li Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance Frontiers in Microbiology FosB fosfomycin antibiotic resistance proteins gut microbiota Staphylococcus |
author_facet |
Ziwei Song Ziwei Song Ziwei Song Xue Wang Xue Wang Xingchen Zhou Xingchen Zhou Su Jiang Yuanyuan Li Owais Ahmad Owais Ahmad Owais Ahmad Lianwen Qi Lianwen Qi Ping Li Ping Li Jing Li Jing Li |
author_sort |
Ziwei Song |
title |
Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance |
title_short |
Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance |
title_full |
Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance |
title_fullStr |
Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance |
title_full_unstemmed |
Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance |
title_sort |
taxonomic distribution of fosb in human-microbiota and activity comparison of fosfomycin resistance |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2019-02-01 |
description |
FosB, a Mg2+ dependent thioltransferase, confers antibiotic resistance to fosfomycin through enzymatic drug inactivation. Among all antibiotic resistant proteins in the Antibiotic Resistance Genes Database and the Comprehensive Antibiotic Resistance Database, FosB is within 5% of the most number of ARPs identified in Human Microbiome Project reference database but mainly distributed in limited genera, i.e., 122 of total 133 FosB homologues are found from Bacillus and Staphylococcus. Furthermore, these FosB sequences could be divided into three clusters based on their phylogenetic relationship, i.e., two groups of FosB were mainly from Bacillus, and another was mainly from Staphylococcus. Finally, we confirmed that FosB from the group of Staphylococcus presented the highest resistance ability to fosfomycin by in silico and in vitro comparisons. In summary, this study elaborates the specific taxonomic characteristics and resistant abilities of FosB in human microbiota, which might help in developing more promising fosfomycin-like antibiotics. |
topic |
FosB fosfomycin antibiotic resistance proteins gut microbiota Staphylococcus |
url |
https://www.frontiersin.org/article/10.3389/fmicb.2019.00200/full |
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