Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

Jens Hagenow,1 Stefanie Hagenow,1 Kathrin Grau,1 Mohammad Khanfar,1– 3 Lena Hefke,4 Ewgenij Proschak,4 Holger Stark1 1Heinrich Heine University Düsseldorf, Institute of Pharmaceutical and Medicinal Chemistry, Duesseldorf 40225, Germany; 2Faculty of Pharmacy, The University of Jord...

Full description

Bibliographic Details
Main Authors:	Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H
Format:	Article
Language:	English
Published:	Dove Medical Press 2020-01-01
Series:	Drug Design, Development and Therapy
Subjects:	salicylic acid derivatives molecular modeling parkinson’s disease enzyme inhibitor pharmacophore structure-activity relationships
Online Access:	https://www.dovepress.com/reversible-small-molecule-inhibitors-of-mao-a-and-mao-b-with-anilide-m-peer-reviewed-article-DDDT

Similar Items

Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors
by: Swatantra K. Jain, et al.
Published: (2007-09-01)

The treatment of Parkinson's disease using MAO-B inhibitors
by: Parsons, Austin
Published: (2017)

Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
by: John Paul Maurice Finberg, et al.
Published: (2016-10-01)

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
by: Gülhan Turan-Zitouni, et al.
Published: (2018-01-01)

Synthesis and Evaluation of Phenylxanthine Derivatives as Potential Dual A2AR Antagonists/MAO-B Inhibitors for Parkinson’s Disease
by: Xuebao Wang, et al.
Published: (2017-06-01)

Parameters for Irreversible Inactivation of Monoamine Oxidase
by: Rona R. Ramsay, et al.
Published: (2020-12-01)

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson’s disease
by: Serena Vittorio, et al.
Published: (2020-01-01)

Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data
by: Becka M. Warfield, et al.
Published: (2021-10-01)

Pharmacophore modeling and virtual screening for the discovery of new fatty acid amide hydrolase inhibitors
by: Dong-sheng Zhao, et al.
Published: (2011-06-01)

4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
by: Daniela Secci, et al.
Published: (2019-01-01)

Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors
by: Alba Chimirri, et al.
Published: (2011-08-01)

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site
by: Ido Rippin, et al.
Published: (2020-11-01)

Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations
by: You Zhou, et al.
Published: (2019-11-01)

Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening
by: Michael Kirstgen, et al.
Published: (2021-07-01)

Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors
by: Ghadeer Albadawi, et al.
Published: (2010-08-01)

Combined Structure-Based Pharmacophore and 3D-QSAR Studies on Phenylalanine Series Compounds as TPH1 Inhibitors
by: Mingli Xiang, et al.
Published: (2012-05-01)

Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
by: Ajani Olayinka O., et al.
Published: (2019-06-01)

Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies
by: Hana Elshaflu, et al.
Published: (2018-07-01)

Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors
by: Loghman Firoozpour, et al.
Published: (2020-01-01)

Reviewing Ligand-Based Rational Drug Design: The Search for an ATP Synthase Inhibitor
by: Hsueh-Fen Juan, et al.
Published: (2011-08-01)

Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine
by: Fang Lu, et al.
Published: (2016-09-01)

Neuropsychiatrie disorders in Parkinson's disease and their correction with the MAO-B inhibitor rasagiline (Azilect®)
by: M. R. Nodel
Published: (2011-09-01)

Discovery of novel 4-hydroxyquinolines as indoleamine 2, 3-dioxygenase 1 inhibitors by virtual screening
by: ZHANG Yuping, et al.
Published: (2019-08-01)

Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations
by: Tihomir Tomašič, et al.
Published: (2020-09-01)

Effects of combined MAO-B inhibitors and levodopa vs monotherapy in Parkinson’s disease
by: Rakhee eKrishna, et al.
Published: (2014-07-01)

Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration
by: Nikolay T. Tzvetkov, et al.
Published: (2017-01-01)

Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines
by: Jeannette Calderón-Arancibia, et al.
Published: (2015-04-01)

The Antiproliferative Effects of Flavonoid MAO Inhibitors on Prostate Cancer Cells
by: Najla O. Zarmouh, et al.
Published: (2020-05-01)

In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs
by: Zarko Gagic, et al.
Published: (2020-01-01)

Selection of Efficient Inhibitors for Caspas-9 according to Structure-Based Pharmacophore Screening Strategy and Molecular Dynamics Simulations
by: Samira Ansari, et al.
Published: (2020-01-01)

Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
by: Sinem Ilgın, et al.
Published: (2017-12-01)

Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening
by: Noor Atatreh, et al.
Published: (2019-01-01)

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening
by: Kun Yin, et al.
Published: (2019-03-01)

The HDAC/HSP90 Inhibitor G570 Attenuated Blue Light-Induced Cell Migration in RPE Cells and Neovascularization in Mice through Decreased VEGF Production
by: Tai-Ju Hsu, et al.
Published: (2021-07-01)

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif
by: Leonardo Pisani, et al.
Published: (2016-03-01)

Combinatorial Pharmacophore-Based 3D-QSAR Analysis and Virtual Screening of FGFR1 Inhibitors
by: Nannan Zhou, et al.
Published: (2015-06-01)

The Discovery of Potentially Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: A Combination of Pharmacophore Modelling, CoMFA, Virtual Screening and Molecular Docking Studies
by: Guanhong Xu, et al.
Published: (2014-05-01)

Pharmacology of Rasagiline, a New MAO-B Inhibitor Drug for the Treatment of Parkinson’s Disease with Neuroprotective Potential
by: John P.M. Finberg
Published: (2010-07-01)

A Combined Pharmacophore Modeling, 3D QSAR and Virtual Screening Studies on Imidazopyridines as B-Raf Inhibitors
by: Huiding Xie, et al.
Published: (2015-05-01)

Exploration of Novel Xanthine Oxidase Inhibitors Based on 1,6-Dihydropyrimidine-5-Carboxylic Acids by an Integrated in Silico Study
by: Na Zhai, et al.
Published: (2021-07-01)