Evaluation of Ciprofloxacin Cytotoxic Effect in Rat Testis

• Main Authors: Arash Khaki, Mahnaz Heidari, Marefat Ghafari Novin, Amir Afshin Khaki, Farzad Rejaie
• Format: Article
• Language: fas
• Published: Hamadan University of Medical Sciences 2007-06-01
• Series: پزشکی بالینی ابن سینا
• Subjects: ciprofloxacin; cytotoxicity; rat; testis
• Online Access: http://sjh.umsha.ac.ir/article-1-449-en.html

Introduction & Objective: Ciprofloxacin is a synthetic antibacterial agent belonging to the family of fluoroquinolones with a very broad spectrum against microbial pathogens, especially Gram-negative infectious diseases, that has been approved in more than 100 countries world-wide. The aim of this study was to see histopathological and cytotoxic effects of ciprofloxacin after inducement in rat testis. Materials & Methods: The twenty male wistar rat were selected and randomly divided into two groups control (n=10) and test (n=10). The test group was received 12.5mg/kg (PO) ciprofloxacin daily for sixty day however the control group just received plate. On sixtieth day the testis tissue of rat in both groups were removed and were prepared for light microscopy and cytotoxic studies. Results: Study about cytotoxic effects was indicated that absorption of radiation rate after five day in control group was increased when as compared with experimental group, (Control: 92.8±1.5 & Test: 65±6, P<0.05) and the studies of testis tissue slices of test group showed many changes such as necrosis in spermatocyt I cells plus diameter of nuclei in spermatocyt I, was increased, (P<0.01). Conclusion: Since in our study ciprofloxacin had cytotoxic side effect on spermatocyt I cells, and rate of cell death may be increased in this cells then consequently ciprofloxacin inducement is harmful for sperm health ability parameters and due decrease fertility rates in human.