Advances of PD-1/PD-L1 Signaling Pathway in Immune Escape and Treatment for Non-small Cell Lung Cancer
Lung cancer is the leading cause of cancer-related mortality worldwide. Despiting the great progress on target agents, majority of people who do not harbor a mutation could not get benefit from them. Immunotherapy, through stimulating the body's immune system to improve the antitumor immunity e...
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2014-10-01
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Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2014.10.05 |
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doaj-8fed973bdc3842a1adc7ff863e798a482020-11-24T23:22:31ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34192014-10-01171073474010.3779/j.issn.1009-3419.2014.10.05Advances of PD-1/PD-L1 Signaling Pathway in Immune Escape and Treatment for
Non-small Cell Lung CancerCheng LIN0Xiong CHEN1Jingnan LIU2Yufang HUANG3Xuenong OU-YANG4Nanjing Military Command Fuzhou General Hospital, Fuzhou 350025, ChinaNanjing Military Command Fuzhou General Hospital, Fuzhou 350025, ChinaNanjing Military Command Fuzhou General Hospital, Fuzhou 350025, ChinaNanjing Military Command Fuzhou General Hospital, Fuzhou 350025, ChinaNanjing Military Command Fuzhou General Hospital, Fuzhou 350025, ChinaLung cancer is the leading cause of cancer-related mortality worldwide. Despiting the great progress on target agents, majority of people who do not harbor a mutation could not get benefit from them. Immunotherapy, through stimulating the body's immune system to improve the antitumor immunity effect, has been a new therapeutic method for non-small cell lung cancer (NSCLC). Study had been reported that immune checkpoint molecules, including programmed death-1 (PD-1)/PD-ligand (L) 1 axis, are closedly related with cancer generation and development, and play a key role on clinical significance of NSCLC. Activation of PD-1/PD-L1 pathway contributes to tumor immune escape, and block PD-1/PD-L1 pathway can enhance endogenous antimuor immunity. Currently increasing clinical trials suggested that immune checkpoint inhibitors, including anti-PD-1 and anti-PD-L1 monoclonal antibodies turned out to be beneficial and safe in NSCLC. Here, we provide a review on the progress of PD-1/PD-L1 pathway and immune checkpoint inhibitors in NSCLC.http://dx.doi.org/10.3779/j.issn.1009-3419.2014.10.05Lung neoplasmsProgrammed death 1Programmed death 1 ligandImmuno-therapyCheckpoint inhibitorsImmune escape |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
Cheng LIN Xiong CHEN Jingnan LIU Yufang HUANG Xuenong OU-YANG |
spellingShingle |
Cheng LIN Xiong CHEN Jingnan LIU Yufang HUANG Xuenong OU-YANG Advances of PD-1/PD-L1 Signaling Pathway in Immune Escape and Treatment for Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms Programmed death 1 Programmed death 1 ligand Immuno-therapy Checkpoint inhibitors Immune escape |
author_facet |
Cheng LIN Xiong CHEN Jingnan LIU Yufang HUANG Xuenong OU-YANG |
author_sort |
Cheng LIN |
title |
Advances of PD-1/PD-L1 Signaling Pathway in Immune Escape and Treatment for
Non-small Cell Lung Cancer |
title_short |
Advances of PD-1/PD-L1 Signaling Pathway in Immune Escape and Treatment for
Non-small Cell Lung Cancer |
title_full |
Advances of PD-1/PD-L1 Signaling Pathway in Immune Escape and Treatment for
Non-small Cell Lung Cancer |
title_fullStr |
Advances of PD-1/PD-L1 Signaling Pathway in Immune Escape and Treatment for
Non-small Cell Lung Cancer |
title_full_unstemmed |
Advances of PD-1/PD-L1 Signaling Pathway in Immune Escape and Treatment for
Non-small Cell Lung Cancer |
title_sort |
advances of pd-1/pd-l1 signaling pathway in immune escape and treatment for
non-small cell lung cancer |
publisher |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
series |
Chinese Journal of Lung Cancer |
issn |
1009-3419 |
publishDate |
2014-10-01 |
description |
Lung cancer is the leading cause of cancer-related mortality worldwide. Despiting the great progress on target agents, majority of people who do not harbor a mutation could not get benefit from them. Immunotherapy, through stimulating the body's immune system to improve the antitumor immunity effect, has been a new therapeutic method for non-small cell lung cancer (NSCLC). Study had been reported that immune checkpoint molecules, including programmed death-1 (PD-1)/PD-ligand (L) 1 axis, are closedly related with cancer generation and development, and play a key role on clinical significance of NSCLC. Activation of PD-1/PD-L1 pathway contributes to tumor immune escape, and block PD-1/PD-L1 pathway can enhance endogenous antimuor immunity. Currently increasing clinical trials suggested that immune checkpoint inhibitors, including anti-PD-1 and anti-PD-L1 monoclonal antibodies turned out to be beneficial and safe in NSCLC. Here, we provide a review on the progress of PD-1/PD-L1 pathway and immune checkpoint inhibitors in NSCLC. |
topic |
Lung neoplasms Programmed death 1 Programmed death 1 ligand Immuno-therapy Checkpoint inhibitors Immune escape |
url |
http://dx.doi.org/10.3779/j.issn.1009-3419.2014.10.05 |
work_keys_str_mv |
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