Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium
Background. Acupuncture preconditioning was able to reduce the extent of ischaemia reperfusion (I/R) injury. Previous studies have shown that electroacupuncture (EA) pretreatment at T4-T5 Jiaji (EX-B2) acupoints had cardioprotective effects against myocardial I/R injury. However, the molecular mecha...
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doaj-8fefddb9ceeb4db9b356768eaea516792020-12-21T11:41:30ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882020-01-01202010.1155/2020/88540338854033Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat MyocardiumNing Xiao0Yang Li1Ming-lu Shao2Hua-feng Cui3Chang-yun Zhang4Su-ping Kong5Xin Zhang6Hui-juan Yu7Qi-wen Tan8College of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaCollege of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaCollege of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaHospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaHospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaHospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaCollege of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaCollege of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaCollege of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, ChinaBackground. Acupuncture preconditioning was able to reduce the extent of ischaemia reperfusion (I/R) injury. Previous studies have shown that electroacupuncture (EA) pretreatment at T4-T5 Jiaji (EX-B2) acupoints had cardioprotective effects against myocardial I/R injury. However, the molecular mechanism remains inconclusive. Methods. Wistar rats were pretreated with electroacupuncture for 7 days at the Neiguan (PC6), T4-T5 Jiaji (EX-B2), Yanglingquan (GB34), and Quchi (LI11) acupoints, which belong to different meridians. Then, we investigated the genome-wide gene expression profiles of rats prestimulated at these acupoints after I/R injury. Results. Our study revealed previously unknown cardioprotective roles of T4-T5 Jiaji (EX-B2) acupoints in the I/R progression. The extent of myocardial injury was significantly decreased in the Jiaji group compared with the I/R group. In addition, our data are among the first to link the EA preconditioning at Neiguan (PC6) acupoints and circadian rhythm in the I/R model. Also, for the first time, we explored the meridian and acupoint specificity involved in EA pretreatment at the heart meridian, in which Yanglingquan and Quchi acupoints were selected as the control group for heart-divergent-meridian and nonheart-meridian acupoints. Conclusions. The present study suggested that EA pretreatment at Jiaji alters genome-wide gene expression and protects the rat myocardium against I/R injury, which are most likely through neurohumoral regulation.http://dx.doi.org/10.1155/2020/8854033 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ning Xiao Yang Li Ming-lu Shao Hua-feng Cui Chang-yun Zhang Su-ping Kong Xin Zhang Hui-juan Yu Qi-wen Tan |
spellingShingle |
Ning Xiao Yang Li Ming-lu Shao Hua-feng Cui Chang-yun Zhang Su-ping Kong Xin Zhang Hui-juan Yu Qi-wen Tan Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium Evidence-Based Complementary and Alternative Medicine |
author_facet |
Ning Xiao Yang Li Ming-lu Shao Hua-feng Cui Chang-yun Zhang Su-ping Kong Xin Zhang Hui-juan Yu Qi-wen Tan |
author_sort |
Ning Xiao |
title |
Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium |
title_short |
Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium |
title_full |
Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium |
title_fullStr |
Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium |
title_full_unstemmed |
Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium |
title_sort |
jiaji (ex-b2)-based electroacupuncture preconditioning attenuates early ischaemia reperfusion injury in the rat myocardium |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2020-01-01 |
description |
Background. Acupuncture preconditioning was able to reduce the extent of ischaemia reperfusion (I/R) injury. Previous studies have shown that electroacupuncture (EA) pretreatment at T4-T5 Jiaji (EX-B2) acupoints had cardioprotective effects against myocardial I/R injury. However, the molecular mechanism remains inconclusive. Methods. Wistar rats were pretreated with electroacupuncture for 7 days at the Neiguan (PC6), T4-T5 Jiaji (EX-B2), Yanglingquan (GB34), and Quchi (LI11) acupoints, which belong to different meridians. Then, we investigated the genome-wide gene expression profiles of rats prestimulated at these acupoints after I/R injury. Results. Our study revealed previously unknown cardioprotective roles of T4-T5 Jiaji (EX-B2) acupoints in the I/R progression. The extent of myocardial injury was significantly decreased in the Jiaji group compared with the I/R group. In addition, our data are among the first to link the EA preconditioning at Neiguan (PC6) acupoints and circadian rhythm in the I/R model. Also, for the first time, we explored the meridian and acupoint specificity involved in EA pretreatment at the heart meridian, in which Yanglingquan and Quchi acupoints were selected as the control group for heart-divergent-meridian and nonheart-meridian acupoints. Conclusions. The present study suggested that EA pretreatment at Jiaji alters genome-wide gene expression and protects the rat myocardium against I/R injury, which are most likely through neurohumoral regulation. |
url |
http://dx.doi.org/10.1155/2020/8854033 |
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