Analysis of Association between IL-17 gene rs2275913 Single Nucleotide Polymorphism and Chronic Hepatitis B Infection

• Main Authors: H Tayefinasrabadi, SR Mohebbi, P Azimzadeh, B Hatami, Sh Kazemian, M Saeedi Niasar, A Sharifian, M Zali
• Format: Article
• Language: English
• Published: Babol University of Medical Sciences 2018-01-01
• Series: Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul
• Subjects: Hepatitis B virus; Interleukin-17; Single Nucleotide Polymorphism
• Online Access: http://jbums.org/browse.php?a_code=A-10-3428-1&slc_lang=en&sid=1

BACKGROUND AND OBJECTIVE: Hepatitis B disease is one of the main causes of inflammation and liver damage that can lead to chronic hepatitis B virus infection. Single nucleotide polymorphism in the cytokines gene can affect the host immune response. Interleukin 17 produced by Thelper17 cells has been shown to play a role in immune function in infectious and inflammatory diseases. This study was conducted to investigate the association between polymorphism in IL-17 gene (rs2275913) and chronic hepatitis B infection. METHODS: This case-control study was performed on 130 chronic patients as a case group and 130 healthy individuals  as control. Patients with positive result of ELISA test for HBsAg and Anti-HBc Ab and control subjects with negative result of this test were enrolled. PCR-RFLP was used to genotype extracted DNA from blood samples. FINDINGS: The genotype frequencies of rs2275913 did not show significant difference between patients and control groups. Distribution of genotypes inpatients were, 40.8% GG, 41.5% AG, 17.7% AA and in control group were, 42.3% GG, 45.4% AG, 12.3% GG (p=0.469). CONCLUSION: The results of study showed no relation between IL-17 gene polymorphism rs2275913 and chronic HBV.