Effect of zinc and acetate trigonella foenum graecum on the metabolism of nitric oxide in rats with alcohol dependence formed brain

• Main Authors: Lesya Sokur, Ielyzaveta Torgalo
• Format: Article
• Language: English
• Published: PC Technology Center 2017-02-01
• Series: ScienceRise: Biological Science
• Subjects: алкогольна залежність; фенугрек; оцтовокислий цинк; метаболізм; нітрозоли; системне споживання; головний мозок
• Online Access: http://journals.uran.ua/sr_bio/article/view/83076

The influence of zinc acetate and fenugreek (Trigonella foenum) on the metabolism of nitric oxide in the brain of rats with formed alcohol dependence was investigated. To determine the activity of NO-synthase and its' isoforms (cytokine-dependent iNOS and Са2+-dependent cNOS) in brains of rats with formed alcohol addiction. To measure the level of NO2–, NO3– and S-nitrosothioles in brains of rats with formed alcohol addiction. To study the effects of zinc acetate and Fenugreek (Trigonella foenum graecum) on activity of NO-synthase and its' isoforms (cytokine-dependent iNOS and Са2+-dependent cNOS) and level of NO2–, NO3– and S-nitrosothioles in brains of rats with formed alcohol addiction. It was shown that under conditions of consumption of alcohol the appropriate links of NO cycle were activated: NO-synthase (by means of cytokine-dependent iNOS and Ca2+-dependent NO-synthase isoforms in terms of initial studies: 1-4 weeks) and NO deposition as nitrosothiols