The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction

The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction

Alzheimer’s disease (AD) is the most common form of dementia and is distinguished from other dementias by observation of extracellular Amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles, comprised of fibrils of Aβ and tau protein, respectively. At early stages, AD is characterized by m...

Full description

Bibliographic Details
Main Authors: Mahmoud B. Maina, Laura J. Bailey, Aidan J. Doherty, Louise C. Serpell
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Aβ42
oxidative stress
rDNA transcription
rRNA processing
RNA synthesis
protein synthesis
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00220/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00220/full

Similar Items