The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt

Alzheimer disease (AD) is the most prevalent form of dementia. Loss of hippocampal synapses is the first neurodegenerative event in AD. Synaptic loss has been associated with the accumulation in the brain parenchyma of soluble oligomeric forms of amyloid β peptide (Aβ1-42wt). Clinical observations h...

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Bibliographic Details
Main Authors: Sara Cimini, Alessandra Sclip, Simona Mancini, Laura Colombo, Massimo Messa, Alfredo Cagnotto, Giuseppe Di Fede, Fabrizio Tagliavini, Mario Salmona, Tiziana Borsello
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Aβ oligomers
A673V mutation
Cell-permeable peptide
Synaptic injury
Brainbow hippocampal neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115301157

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http://www.sciencedirect.com/science/article/pii/S0969996115301157

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