Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?

Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?

<p>Abstract</p> <p>In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in <it> Dermatophagoides ptero...

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Bibliographic Details
Main Authors: Figueiredo Camila Alexandrina, Rodrigues Laura Cunha, Alcantara-Neves Neuza Maria, Cooper Philip J, Amorim Leila Denise, Silva Nivea Bispo, Cruz Alvaro A, Barreto Mauricio Lima
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Allergy, Asthma & Clinical Immunology
Subjects:
Non-atopic asthma
Cytokines
IFN-g
Monocytes
Atopic-asthma
IgE
Atopy
Online Access:http://www.aacijournal.com/content/8/1/18
Description
Summary:<p>Abstract</p> <p>In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in <it> Dermatophagoides pteronyssinus </it> stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.</p>
ISSN:1710-1484
1710-1492

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