Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?
<p>Abstract</p> <p>In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in <it> Dermatophagoides ptero...
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doaj-900fd2427eda4491a1d47f13141fdce52020-11-24T21:39:42ZengBMCAllergy, Asthma & Clinical Immunology1710-14841710-14922012-12-01811810.1186/1710-1492-8-18Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?Figueiredo Camila AlexandrinaRodrigues Laura CunhaAlcantara-Neves Neuza MariaCooper Philip JAmorim Leila DeniseSilva Nivea BispoCruz Alvaro ABarreto Mauricio Lima<p>Abstract</p> <p>In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in <it> Dermatophagoides pteronyssinus </it> stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.</p> http://www.aacijournal.com/content/8/1/18Non-atopic asthmaCytokinesIFN-gMonocytesAtopic-asthmaIgEAtopy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Figueiredo Camila Alexandrina Rodrigues Laura Cunha Alcantara-Neves Neuza Maria Cooper Philip J Amorim Leila Denise Silva Nivea Bispo Cruz Alvaro A Barreto Mauricio Lima |
spellingShingle |
Figueiredo Camila Alexandrina Rodrigues Laura Cunha Alcantara-Neves Neuza Maria Cooper Philip J Amorim Leila Denise Silva Nivea Bispo Cruz Alvaro A Barreto Mauricio Lima Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children? Allergy, Asthma & Clinical Immunology Non-atopic asthma Cytokines IFN-g Monocytes Atopic-asthma IgE Atopy |
author_facet |
Figueiredo Camila Alexandrina Rodrigues Laura Cunha Alcantara-Neves Neuza Maria Cooper Philip J Amorim Leila Denise Silva Nivea Bispo Cruz Alvaro A Barreto Mauricio Lima |
author_sort |
Figueiredo Camila Alexandrina |
title |
Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children? |
title_short |
Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children? |
title_full |
Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children? |
title_fullStr |
Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children? |
title_full_unstemmed |
Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children? |
title_sort |
does ifn-γ play a role on the pathogenesis of non-atopic asthma in latin america children? |
publisher |
BMC |
series |
Allergy, Asthma & Clinical Immunology |
issn |
1710-1484 1710-1492 |
publishDate |
2012-12-01 |
description |
<p>Abstract</p> <p>In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in <it> Dermatophagoides pteronyssinus </it> stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.</p> |
topic |
Non-atopic asthma Cytokines IFN-g Monocytes Atopic-asthma IgE Atopy |
url |
http://www.aacijournal.com/content/8/1/18 |
work_keys_str_mv |
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