Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst.
Objective: Some species of the Russelia genus have been used different illnesses associated with pain and inflammation. The aim of this work was to characterize the biological activities (anti-inflammatory and analgesic) and antioxidant capacity of methanol and dichloromethane extracts of Russelia...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Mashhad University of Medical Sciences
2021-02-01
|
Series: | Avicenna Journal of Phytomedicine |
Subjects: | |
Online Access: | https://ajp.mums.ac.ir/article_16718_db893852756eb6b99ecd9f2b2d316b4e.pdf |
id |
doaj-90184b4b9c4c4175928c8c034bd2f93a |
---|---|
record_format |
Article |
spelling |
doaj-90184b4b9c4c4175928c8c034bd2f93a2021-02-20T10:06:27ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492021-02-0111210110810.22038/ajp.2020.1671816718Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst.María C. Columba-Palomares0Rosa Mariana Montiel-Ruiz1Lucia Corona Sánchez2Daniel Palafox-Gante3Verónica Rodríguez-López4Laboratory of Chemistry of Natural Products and Pharmacognosy, Faculty of Pharmacy, Autonomous University of the State of Morelos (UAEM). Morelos, México.Laboratory of Pharmacology, Center of Biomedical Research of the South, Mexican Institute of Social Security (IMSS). Morelos, México.Laboratory of Chemistry of Natural Products and Pharmacognosy, Faculty of Pharmacy, Autonomous University of the State of Morelos (UAEM). Morelos, México.Laboratory of Chemistry of Natural Products and Pharmacognosy, Faculty of Pharmacy, Autonomous University of the State of Morelos (UAEM). Morelos, México.Laboratory of Chemistry of Natural Products and Pharmacognosy, Faculty of Pharmacy, Autonomous University of the State of Morelos (UAEM). Morelos, México.Objective: Some species of the Russelia genus have been used different illnesses associated with pain and inflammation. The aim of this work was to characterize the biological activities (anti-inflammatory and analgesic) and antioxidant capacity of methanol and dichloromethane extracts of Russelia coccinea. Materials and Methods: In this study, topical anti-inflammatory activity was tested in an in vivo model of 12-O-tetradecanoylphorbol acetate (TPA) induced mouse ear edema of organic extracts (doses: 0.03, 0.1, and 0.3 mg/ear). The antinociceptive activity was assessed using the formalin test in mice of organic extracts (doses: 56, 100 and 300 mg/kg ). Moreover, the antioxidant capacity of the extracts was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiaziline-6-sulfonate) (ABTS) and ferric reducing antioxidant power (FRAP) assays. Results: Methanol (RcM) and dichloromethane (RcD) extracts of the R. coccinea aerial parts were found to inhibit ear edema (48.95 and 40.13%, respectively) at a dose of 0.3 mg/ear. Acute treatment with RcM produced a significant antinociceptive effect in the late phase of formalin-induced nociception. Moreover, RcM at doses of 56, 100 and 300 mg/kg showed a significant antinociceptive effect through the early and late phases in the formalin test. RcM and RcD showed weak antioxidant capacities in the ABTS and DPPH assays; however, when their reducing capacity was evaluated by the FRAP assay, RcM showed a reducing activity similar to Camellia sinensis standard at the proven concentration of 1000 μg/ml. Conclusion: According to the experimental findings, the organic extracts of R. coccinea display remarkable antinociceptive and anti-inflammatory activities.https://ajp.mums.ac.ir/article_16718_db893852756eb6b99ecd9f2b2d316b4e.pdfrusselia coccineaplantaginaceaeanti-inflammatory activityantinociceptive activityorganic extractsantioxidant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María C. Columba-Palomares Rosa Mariana Montiel-Ruiz Lucia Corona Sánchez Daniel Palafox-Gante Verónica Rodríguez-López |
spellingShingle |
María C. Columba-Palomares Rosa Mariana Montiel-Ruiz Lucia Corona Sánchez Daniel Palafox-Gante Verónica Rodríguez-López Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst. Avicenna Journal of Phytomedicine russelia coccinea plantaginaceae anti-inflammatory activity antinociceptive activity organic extracts antioxidant |
author_facet |
María C. Columba-Palomares Rosa Mariana Montiel-Ruiz Lucia Corona Sánchez Daniel Palafox-Gante Verónica Rodríguez-López |
author_sort |
María C. Columba-Palomares |
title |
Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst. |
title_short |
Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst. |
title_full |
Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst. |
title_fullStr |
Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst. |
title_full_unstemmed |
Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst. |
title_sort |
anti-inflammatory, antioxidant and antinociceptive activities of russelia coccinea (l.) wettst. |
publisher |
Mashhad University of Medical Sciences |
series |
Avicenna Journal of Phytomedicine |
issn |
2228-7930 2228-7949 |
publishDate |
2021-02-01 |
description |
Objective: Some species of the Russelia genus have been used different illnesses associated with pain and inflammation. The aim of this work was to characterize the biological activities (anti-inflammatory and analgesic) and antioxidant capacity of methanol and dichloromethane extracts of Russelia coccinea. Materials and Methods: In this study, topical anti-inflammatory activity was tested in an in vivo model of 12-O-tetradecanoylphorbol acetate (TPA) induced mouse ear edema of organic extracts (doses: 0.03, 0.1, and 0.3 mg/ear). The antinociceptive activity was assessed using the formalin test in mice of organic extracts (doses: 56, 100 and 300 mg/kg ). Moreover, the antioxidant capacity of the extracts was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiaziline-6-sulfonate) (ABTS) and ferric reducing antioxidant power (FRAP) assays. Results: Methanol (RcM) and dichloromethane (RcD) extracts of the R. coccinea aerial parts were found to inhibit ear edema (48.95 and 40.13%, respectively) at a dose of 0.3 mg/ear. Acute treatment with RcM produced a significant antinociceptive effect in the late phase of formalin-induced nociception. Moreover, RcM at doses of 56, 100 and 300 mg/kg showed a significant antinociceptive effect through the early and late phases in the formalin test. RcM and RcD showed weak antioxidant capacities in the ABTS and DPPH assays; however, when their reducing capacity was evaluated by the FRAP assay, RcM showed a reducing activity similar to Camellia sinensis standard at the proven concentration of 1000 μg/ml. Conclusion: According to the experimental findings, the organic extracts of R. coccinea display remarkable antinociceptive and anti-inflammatory activities. |
topic |
russelia coccinea plantaginaceae anti-inflammatory activity antinociceptive activity organic extracts antioxidant |
url |
https://ajp.mums.ac.ir/article_16718_db893852756eb6b99ecd9f2b2d316b4e.pdf |
work_keys_str_mv |
AT mariaccolumbapalomares antiinflammatoryantioxidantandantinociceptiveactivitiesofrusseliacoccinealwettst AT rosamarianamontielruiz antiinflammatoryantioxidantandantinociceptiveactivitiesofrusseliacoccinealwettst AT luciacoronasanchez antiinflammatoryantioxidantandantinociceptiveactivitiesofrusseliacoccinealwettst AT danielpalafoxgante antiinflammatoryantioxidantandantinociceptiveactivitiesofrusseliacoccinealwettst AT veronicarodriguezlopez antiinflammatoryantioxidantandantinociceptiveactivitiesofrusseliacoccinealwettst |
_version_ |
1724259884853100544 |