Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections
Background: Biomarkers specificity is an important factor for their reliable utilization. Known markers for acute myocardial infarction (AMI), including creatine kinase (CK), C-reactive protein (CRP), and blood cell counts are thought to be altered in other pathologic conditions, such as infections....
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Wolters Kluwer Medknow Publications
2012-01-01
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doaj-9025605de3664c3ab5b0495b433727452020-11-24T21:32:30ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292012-01-0155447447710.4103/0377-4929.107783Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infectionsHaseeb A KhanAbdullah S AlhomidaSamia H SobkiAbdulrahman Al MoghairiBackground: Biomarkers specificity is an important factor for their reliable utilization. Known markers for acute myocardial infarction (AMI), including creatine kinase (CK), C-reactive protein (CRP), and blood cell counts are thought to be altered in other pathologic conditions, such as infections. Aim: To compare the level of these biomarkers in AMI patients and infected controls with respect to normal subjects. Materials and Methods: We recruited 15 AMI patients, 15 patients with bacterial infections (infected control group) and 35 normal subjects. Peripheral blood samples were obtained for blood cell counts and biochemical analyses. Results: Only monocytes were significantly increased in AMI patients (0.793 × 10 9 /L) than normal controls (0.497 × 10 9 /L). Infected controls showed a significant increase in total white blood cell (11.50 × 10 9 /L versus 6.149 × 10 9 /L) and neutrophil (9.360 versus 3.223 × 10 9 /L) counts and a significant decrease in red blood cell (3.750 versus 5.105 × 10 12 /L) counts as compared with normal controls. Serum CK was significantly increased in AMI patients (313.20 ± 94.84 U/L) and decreased in infected controls (48.40 ± 10.35 U/L) as compared with normal controls (100.82 ± 8.86 U/L). The levels of CRP were significantly higher in infected controls (136.93 ± 34.83 mg/L) and nonsignificantly higher in AMI patients (38.53 ± 12.76 mg/L) than normal controls (3.48 ± 0.59 mg/L). Monocytes were significantly correlated with both CK and CRP; however, there was no correlation between CK and CRP. Conclusion: Differential trends of monocytes and CK in AMI and infective controls point toward their possible application in prognosis of AMI patients.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=4;spage=474;epage=477;aulast=KhanAcute myocardial infarctionbiomarkerblood cellsC-reactive proteincreatine kinaseinflammationinfection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haseeb A Khan Abdullah S Alhomida Samia H Sobki Abdulrahman Al Moghairi |
spellingShingle |
Haseeb A Khan Abdullah S Alhomida Samia H Sobki Abdulrahman Al Moghairi Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections Indian Journal of Pathology and Microbiology Acute myocardial infarction biomarker blood cells C-reactive protein creatine kinase inflammation infection |
author_facet |
Haseeb A Khan Abdullah S Alhomida Samia H Sobki Abdulrahman Al Moghairi |
author_sort |
Haseeb A Khan |
title |
Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections |
title_short |
Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections |
title_full |
Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections |
title_fullStr |
Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections |
title_full_unstemmed |
Significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections |
title_sort |
significant increases in monocyte counts and serum creatine kinase in acute myocardial infarction versus general infections |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Pathology and Microbiology |
issn |
0377-4929 |
publishDate |
2012-01-01 |
description |
Background: Biomarkers specificity is an important factor for their reliable utilization. Known markers for acute myocardial infarction (AMI), including creatine kinase (CK), C-reactive protein (CRP), and blood cell counts are thought to be altered in other pathologic conditions, such as infections. Aim: To compare the level of these biomarkers in AMI patients and infected controls with respect to normal subjects. Materials and Methods: We recruited 15 AMI patients, 15 patients with bacterial infections (infected control group) and 35 normal subjects. Peripheral blood samples were obtained for blood cell counts and biochemical analyses. Results: Only monocytes were significantly increased in AMI patients (0.793 × 10 9 /L) than normal controls (0.497 × 10 9 /L). Infected controls showed a significant increase in total white blood cell (11.50 × 10 9 /L versus 6.149 × 10 9 /L) and neutrophil (9.360 versus 3.223 × 10 9 /L) counts and a significant decrease in red blood cell (3.750 versus 5.105 × 10 12 /L) counts as compared with normal controls. Serum CK was significantly increased in AMI patients (313.20 ± 94.84 U/L) and decreased in infected controls (48.40 ± 10.35 U/L) as compared with normal controls (100.82 ± 8.86 U/L). The levels of CRP were significantly higher in infected controls (136.93 ± 34.83 mg/L) and nonsignificantly higher in AMI patients (38.53 ± 12.76 mg/L) than normal controls (3.48 ± 0.59 mg/L). Monocytes were significantly correlated with both CK and CRP; however, there was no correlation between CK and CRP. Conclusion: Differential trends of monocytes and CK in AMI and infective controls point toward their possible application in prognosis of AMI patients. |
topic |
Acute myocardial infarction biomarker blood cells C-reactive protein creatine kinase inflammation infection |
url |
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=4;spage=474;epage=477;aulast=Khan |
work_keys_str_mv |
AT haseebakhan significantincreasesinmonocytecountsandserumcreatinekinaseinacutemyocardialinfarctionversusgeneralinfections AT abdullahsalhomida significantincreasesinmonocytecountsandserumcreatinekinaseinacutemyocardialinfarctionversusgeneralinfections AT samiahsobki significantincreasesinmonocytecountsandserumcreatinekinaseinacutemyocardialinfarctionversusgeneralinfections AT abdulrahmanalmoghairi significantincreasesinmonocytecountsandserumcreatinekinaseinacutemyocardialinfarctionversusgeneralinfections |
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