Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective Study
Background. To evaluate the role of ultrasonography (US), US-guided fine-needle aspiration (USFNA) and intraoperative frozen section (FS) in follicular neoplasm. Methods. US features, USFNA cytology, and FS results were compared based on the pathology results of patients with follicular adenoma (FA)...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2014-01-01
|
Series: | International Journal of Endocrinology |
Online Access: | http://dx.doi.org/10.1155/2014/321595 |
id |
doaj-902e52dd70aa49c286de14bdbc18c432 |
---|---|
record_format |
Article |
spelling |
doaj-902e52dd70aa49c286de14bdbc18c4322020-11-24T23:08:41ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/321595321595Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective StudyJung Hyun Yoon0Eun-Kyung Kim1Ji Hyun Youk2Hee Jung Moon3Jin Young Kwak4Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaBackground. To evaluate the role of ultrasonography (US), US-guided fine-needle aspiration (USFNA) and intraoperative frozen section (FS) in follicular neoplasm. Methods. US features, USFNA cytology, and FS results were compared based on the pathology results of patients with follicular adenoma (FA), follicular carcinoma (FC), and follicular variant of papillary thyroid carcinoma (FVPTC). Results. FC and FVPTC showed significantly higher rates of suspicious US features (P<0.05) and positive findings on either US or cytology, 80.0% and 90.7%, compared to FA, 64.5% (P=0.001). Intraoperative FS showed higher malignant rates in FVPTC and FC (81.8% and 75.0%, resp.), compared to FA (3.8%, P<0.001). Conclusion. Suspicious US features were more significantly seen in FC and FVPTC compared to FA. Intraoperative FS is useful in the differential diagnosis of these lesions and supplements cytology results of USFNA.http://dx.doi.org/10.1155/2014/321595 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jung Hyun Yoon Eun-Kyung Kim Ji Hyun Youk Hee Jung Moon Jin Young Kwak |
spellingShingle |
Jung Hyun Yoon Eun-Kyung Kim Ji Hyun Youk Hee Jung Moon Jin Young Kwak Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective Study International Journal of Endocrinology |
author_facet |
Jung Hyun Yoon Eun-Kyung Kim Ji Hyun Youk Hee Jung Moon Jin Young Kwak |
author_sort |
Jung Hyun Yoon |
title |
Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective Study |
title_short |
Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective Study |
title_full |
Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective Study |
title_fullStr |
Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective Study |
title_full_unstemmed |
Better Understanding in the Differentiation of Thyroid Follicular Adenoma, Follicular Carcinoma, and Follicular Variant of Papillary Carcinoma: A Retrospective Study |
title_sort |
better understanding in the differentiation of thyroid follicular adenoma, follicular carcinoma, and follicular variant of papillary carcinoma: a retrospective study |
publisher |
Hindawi Limited |
series |
International Journal of Endocrinology |
issn |
1687-8337 1687-8345 |
publishDate |
2014-01-01 |
description |
Background. To evaluate the role of ultrasonography (US), US-guided fine-needle aspiration (USFNA) and intraoperative frozen section (FS) in follicular neoplasm. Methods. US features, USFNA cytology, and FS results were compared based on the pathology results of patients with follicular adenoma (FA), follicular carcinoma (FC), and follicular variant of papillary thyroid carcinoma (FVPTC). Results. FC and FVPTC showed significantly higher rates of suspicious US features (P<0.05) and positive findings on either US or cytology, 80.0% and 90.7%, compared to FA, 64.5% (P=0.001). Intraoperative FS showed higher malignant rates in FVPTC and FC (81.8% and 75.0%, resp.), compared to FA (3.8%, P<0.001). Conclusion. Suspicious US features were more significantly seen in FC and FVPTC compared to FA. Intraoperative FS is useful in the differential diagnosis of these lesions and supplements cytology results of USFNA. |
url |
http://dx.doi.org/10.1155/2014/321595 |
work_keys_str_mv |
AT junghyunyoon betterunderstandinginthedifferentiationofthyroidfollicularadenomafollicularcarcinomaandfollicularvariantofpapillarycarcinomaaretrospectivestudy AT eunkyungkim betterunderstandinginthedifferentiationofthyroidfollicularadenomafollicularcarcinomaandfollicularvariantofpapillarycarcinomaaretrospectivestudy AT jihyunyouk betterunderstandinginthedifferentiationofthyroidfollicularadenomafollicularcarcinomaandfollicularvariantofpapillarycarcinomaaretrospectivestudy AT heejungmoon betterunderstandinginthedifferentiationofthyroidfollicularadenomafollicularcarcinomaandfollicularvariantofpapillarycarcinomaaretrospectivestudy AT jinyoungkwak betterunderstandinginthedifferentiationofthyroidfollicularadenomafollicularcarcinomaandfollicularvariantofpapillarycarcinomaaretrospectivestudy |
_version_ |
1725613034900029440 |