Identification and characterization of ZEL-H16 as a novel agonist of the histamine H3 receptor.

Identification and characterization of ZEL-H16 as a novel agonist of the histamine H3 receptor.

The histamine H3 receptor (H3R) has been recognized as a promising target for the treatment of various central and peripheral nervous system diseases. In this study, a non-imidazole compound, ZEL-H16, was identified as a novel histamine H3 receptor agonist. ZEL-H16 was found to bind to human H3R wit...

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Bibliographic Details
Main Authors: Ying Shi, Rong Sheng, Tingting Zhong, Yu Xu, Xiaopan Chen, Dong Yang, Yi Sun, Fenyan Yang, Yongzhou Hu, Naiming Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3411647?pdf=render

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