Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, Nigeria

Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, Nigeria

<p>Abstract</p> <p>We report the first <it>in vitro</it> and genetic confirmation of Malarone<sup>®</sup> (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in <it>Plasmodium falciparum</it> acquired in Africa. On presenting wit...

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Main Authors: Warhurst David C, Adagu Ipemida S, Butcher Geoffrey A, Fivelman Quinton L, Pasvol Geoffrey
Format: Article
Language:English
Published: BMC 2002-02-01
Series:Malaria Journal
Online Access:http://www.malariajournal.com/content/1/1/1
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spelling doaj-9032c516f1a240ebacced2ef86cd7fdc2020-11-25T00:58:55ZengBMCMalaria Journal1475-28752002-02-0111110.1186/1475-2875-1-1Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, NigeriaWarhurst David CAdagu Ipemida SButcher Geoffrey AFivelman Quinton LPasvol Geoffrey<p>Abstract</p> <p>We report the first <it>in vitro</it> and genetic confirmation of Malarone<sup>®</sup> (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in <it>Plasmodium falciparum</it> acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone<sup>®</sup>. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome <it>b</it> gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.</p> http://www.malariajournal.com/content/1/1/1
collection DOAJ
language English
format Article
sources DOAJ
author Warhurst David C
Adagu Ipemida S
Butcher Geoffrey A
Fivelman Quinton L
Pasvol Geoffrey
spellingShingle Warhurst David C
Adagu Ipemida S
Butcher Geoffrey A
Fivelman Quinton L
Pasvol Geoffrey
Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, Nigeria
Malaria Journal
author_facet Warhurst David C
Adagu Ipemida S
Butcher Geoffrey A
Fivelman Quinton L
Pasvol Geoffrey
author_sort Warhurst David C
title Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, Nigeria
title_short Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, Nigeria
title_full Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, Nigeria
title_fullStr Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, Nigeria
title_full_unstemmed Malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>Plasmodium falciparum</it> isolate from Lagos, Nigeria
title_sort malarone treatment failure and <it>in vitro</it> confirmation of resistance of <it>plasmodium falciparum</it> isolate from lagos, nigeria
publisher BMC
series Malaria Journal
issn 1475-2875
publishDate 2002-02-01
description <p>Abstract</p> <p>We report the first <it>in vitro</it> and genetic confirmation of Malarone<sup>®</sup> (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in <it>Plasmodium falciparum</it> acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone<sup>®</sup>. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome <it>b</it> gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.</p>
url http://www.malariajournal.com/content/1/1/1
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